Breast Cancer Research and Treatment

, Volume 90, Issue 3, pp 257–261 | Cite as

Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan

  • Nai-Wen Chang
  • Dar-Ren Chen
  • Chen-Ten Wu
  • Bradley E. Aouizerat
  • Fei-Na Chen
  • Shin-Jer Hung
  • Shiuan-Huei Wang
  • Ming-Feng Wei
  • Cheng-Shyong Chang


Apolipoprotein E (APOE) polymorphism plays an important role in lipid metabolism. Preliminary evidence suggests that APOE genotype appears to be a risk factor for not only cardiovascular disease, but also Alzheimer’s disease and cancer. We screened the APOE genotype in 290 breast cancer patients and 232 non-cancer controls and determined the relationship between APOE gene polymorphism and breast cancer in Taiwan. We found risk for breast cancer was associated with the APOE genotype (ξ2 = 8.652, p = 0.013). Carriers of the ε4 allele were more common in breast cancer cases than carriers of ε3 allele (p = 0.004, OR = 1.786, 95% CI: 1.197–2.664). In addition, the ε4 allele is also associated with HER2/neu negative status in breast cancer patients (p = 0.006, OR = 0.277, 95% CI: 0.111–0.693). No significant associations between APOE genotype and tumor grade, TN classification, progesterone receptor, estrogen receptor, lymphatic invasion, or recurrence of breast cancer were in evidence. These results suggest that the APOE ε4 allele may be a risk factor for breast cancer and correlates with HER2/neu negative status.


apolipoprotein E polymorphism breast cancer HER2/neu 


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Copyright information

© Springer 2005

Authors and Affiliations

  • Nai-Wen Chang
    • 1
  • Dar-Ren Chen
    • 2
  • Chen-Ten Wu
    • 3
  • Bradley E. Aouizerat
    • 4
  • Fei-Na Chen
    • 5
  • Shin-Jer Hung
    • 6
  • Shiuan-Huei Wang
    • 7
  • Ming-Feng Wei
    • 1
  • Cheng-Shyong Chang
    • 8
  1. 1.Department of Biochemistry, College of MedicineChina Medical UniversityTaichungTaiwan
  2. 2.Department of SurgeryChanghua Christian HospitalTaiwan
  3. 3.Department of HealthExecutive Yuan, Feng-Yuan HospitalTaiwan
  4. 4.Department of Physiological NursingUniversity of CaliforniaSan FranciscoUSA
  5. 5.Department of Social MedicineChina Medical UniversityTaiwan
  6. 6.Department of surgeryChina Medical University HospitalTaiwan
  7. 7.Chinese Blood Services Foundation Taichung Blood CenterTaichungTaiwan
  8. 8.Department of Medical OncologyChanghua Christian HospitalTaiwan

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