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Breast Cancer Research and Treatment

, Volume 89, Issue 3, pp 237–241 | Cite as

Efficacy of weekly paclitaxel in patients with docetaxel-resistant metastatic breast cancer

  • Kan Yonemori
  • Noriyuki Katsumata
  • Hajime Uno
  • Koji Matsumoto
  • Tsutomu Kouno
  • Shinya Tokunaga
  • Yasuhiro Yamanaka
  • Chikako Shimizu
  • Masashi Ando
  • Masahiro Takeuchi
  • Yasuhiro Fujiwara
Report

Summary

Background. Partial cross-resistance to paclitaxel and docetaxel has been demonstrated in pre-clinical studies.

Patients and methods. We retrospectively evaluated the efficacy of weekly paclitaxel 80 mg/m2 in 82 patients with docetaxel-resisitant metastatic breast cancer. Docetaxel resistance was classified into primary resistance, defined as progressive disease while receiving docetaxel, and secondary resistance, defined as progression after achievement of a documented clinical response to docetaxel. Secondary resistance was subclassified according to the interval between the final infusion of docetaxel and the start of weekly paclitaxel into: (1) short interval, ≦120 days, and (2) long interval, >120 days.

Results. The response rate of the 82 patients was 19.5% (95% confidence interval, 10.8–27.9%). The response rate according to the docetaxel resistance category was: primary resistance (n=24), 8.3%; secondary resistance (n=58), 24.1% (short interval [n=39], 17.9%, and long interval, [n=19], 36.8%). The differences in response rates among the three categories were statistically significant (p=0.0247, Cochran–Mantel–Haenszel test). The interval between from the final docetaxel infusion and disease progression were predictors for response of weekly paclitaxel.

Conclusion. Weekly paclitaxel is modestly effective and safe in docetaxel-resistant metastatic breast cancer patients. However, weekly paclitaxel should not be recommended for primary resistance patients with docetaxel.

Keywords

docetaxel metastatic breast cancer paclitaxel predictive factor resistance taxane 

Abbreviations

MBC

metastatic breast cancer

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Copyright information

© Springer 2005

Authors and Affiliations

  • Kan Yonemori
    • 1
  • Noriyuki Katsumata
    • 1
  • Hajime Uno
    • 2
  • Koji Matsumoto
    • 1
  • Tsutomu Kouno
    • 1
  • Shinya Tokunaga
    • 1
  • Yasuhiro Yamanaka
    • 1
  • Chikako Shimizu
    • 1
  • Masashi Ando
    • 1
  • Masahiro Takeuchi
    • 2
  • Yasuhiro Fujiwara
    • 1
  1. 1.Breast and Medical Oncology Division, Department of Medical OncologyNational Cancer Center HospitalTokyoJapan
  2. 2.Division of BiostatisticsKitasato University Graduate SchoolMinato-ku, TokyoJapan

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