Brain Topography

, Volume 31, Issue 2, pp 257–269 | Cite as

Mapping Slow Waves by EEG Topography and Source Localization: Effects of Sleep Deprivation

  • Alessia Bersagliere
  • Roberto D. Pascual-Marqui
  • Leila Tarokh
  • Peter Achermann
Original Paper

Abstract

Slow waves are a salient feature of the electroencephalogram (EEG) during non-rapid eye movement (non-REM) sleep. The aim of this study was to assess the topography of EEG power and the activation of brain structures during slow wave sleep under normal conditions and after sleep deprivation. Sleep EEG recordings during baseline and recovery sleep after 40 h of sustained wakefulness were analyzed (eight healthy young men, 27 channel EEG). Power maps were computed for the first non-REM sleep episode (where sleep pressure is highest) in baseline and recovery sleep, at frequencies between 0.5 and 2 Hz. Power maps had a frontal predominance at all frequencies between 0.5 and 2 Hz. An additional occipital focus of activity was observed below 1 Hz. Power maps ≤ 1 Hz were not affected by sleep deprivation, whereas an increase in power was observed in the maps ≥ 1.25 Hz. Based on the response to sleep deprivation, low-delta (0.5–1 Hz) and mid-delta activity (1.25–2 Hz) were dissociated. Electrical sources within the cortex of low- and mid-delta activity were estimated using eLORETA. Source localization revealed a predominantly frontal distribution of activity for low-delta and mid-delta activity. Sleep deprivation resulted in an increase in source strength only for mid-delta activity, mainly in parietal and frontal regions. Low-delta activity dominated in occipital and temporal regions and mid-delta activity in limbic and frontal regions independent of the level of sleep pressure. Both, power maps and electrical sources exhibited trait-like aspects.

Keywords

Sleep homeostasis Sleep slow oscillations Power topography Source localization 

Abbreviations

EEG

Electroencephalogram,

LORETA

Low resolution brain electromagnetic tomography,

non-REM

Non-rapid eye movement (sleep),

REM

Rapid eye movement (sleep),

SEM

Standard error of mean,

SWA

Slow-wave activity (EEG power in 0.75–4.5 Hz range),

SWS

Slow wave sleep

Notes

Acknowledgements

We thank Dr. Alexander Borbély for comments on the manuscript. The study was supported by the Swiss National Science Foundation Grant 320030-130766 and 32003B_146643.

Supplementary material

10548_2017_595_MOESM1_ESM.docx (551 kb)
Supplementary material 1 (DOCX 551 KB)

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Institute of Pharmacology and ToxicologyUniversity of ZurichZurichSwitzerland
  2. 2.Neuroscience Center ZurichUniversity of Zurich and ETH ZurichZurichSwitzerland
  3. 3.The KEY Institute for Brain-Mind Research, Department of Psychiatry, Psychotherapy and PsychosomaticsUniversity Hospital of PsychiatryZurichSwitzerland
  4. 4.University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of BernBernSwitzerland
  5. 5.Zurich Center for Interdisciplinary Sleep ResearchUniversity of ZurichZurichSwitzerland
  6. 6.Zurich Center for Integrative Human PhysiologyUniversity of ZurichZurichSwitzerland

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