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Brain Topography

, Volume 29, Issue 4, pp 539–551 | Cite as

Effects of Dopamine and Serotonin Systems on Modulating Neural Oscillations in Hippocampus-Prefrontal Cortex Pathway in Rats

  • Xiaxia Xu
  • Chenguang Zheng
  • Lei An
  • Rubin Wang
  • Tao Zhang
Original Paper

Abstract

Theta and gamma oscillations are believed to play an important role in cognition and memory, and their phase coupling facilitates the information transmission in hippocampal-cortex network. In a rat model of chronic stress, the phase coupling of both theta and gamma oscillations between ventral hippocampal CA1 (vCA1) and medial prefrontal cortex (mPFC) was found to be disrupted, which was associated with the impaired synaptic plasticity in the pathway. However, little was known about the mechanisms underlying the process. In order to address this issue, both dopamine and serotonin as monoaminergic neurotransmitters were involved in this study, since they were crucial factors in pathological basis of depressive disorder. Local field potentials (LFPs) were recorded simultaneously at both vCA1 and mPFC regions under anesthesia, before and after the injection of dopamine D1 receptor antagonist and 5-HT1A receptor agonist, respectively. The results showed that the blockage of D1 receptor could lead to depression-like decrement on theta phase coupling. In addition, the activation of 5-HT1A receptor enhanced vCA1–mPFC coupling on gamma oscillations, and attenuated CA1 theta-fast gamma cross frequency coupling. These data suggest that the theta phase coupling between vCA1 and mPFC may be modulated by dopamine system that is an underlying mechanism of the cognitive dysfunction in depression. Besides, the serotonergic system is probably involved in the regulation of gamma oscillations coupling in vCA1–mPFC network.

Graphical Abstract

Keywords

Ventral hippocampus Prefrontal cortex Theta rhythm Gamma oscillations Dopamine 5-HT 

Abbreviations

CFC

Cross frequency coupling

CMI

Conditional mutual information

CUS

Chronic unpredictable stresses

DA

Dopamine

fEPSP

Field excitatory postsynaptic potential

EMA

Evolution map approach

LFP

Local field potential

LTP

Long term potentiation

mPFC

Medial prefrontal cortex

PAC

Phase-amplitude coupling

PAC_PLV

Phase-amplitude coupling-phase locking value

PLV

Phase locking value

vCA1

Ventral hippocampal CA1

5-HT

Serotonin

Notes

Acknowledgments

This work was supported by Grants from the National Natural Science Foundation of China (11232005, 31171053), and 111 Project (B08011).

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Xiaxia Xu
    • 1
  • Chenguang Zheng
    • 1
    • 2
  • Lei An
    • 1
  • Rubin Wang
    • 3
  • Tao Zhang
    • 1
  1. 1.College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of EducationNankai UniversityTianjinPeople’s Republic of China
  2. 2.Center for Learning and MemoryThe University of Texas at AustinAustinUSA
  3. 3.Institute for Cognitive NeurodynamicsEast China University of Science and TechnologyShanghaiPeople’s Republic of China

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