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Effects of Dopamine and Serotonin Systems on Modulating Neural Oscillations in Hippocampus-Prefrontal Cortex Pathway in Rats

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Abstract

Theta and gamma oscillations are believed to play an important role in cognition and memory, and their phase coupling facilitates the information transmission in hippocampal-cortex network. In a rat model of chronic stress, the phase coupling of both theta and gamma oscillations between ventral hippocampal CA1 (vCA1) and medial prefrontal cortex (mPFC) was found to be disrupted, which was associated with the impaired synaptic plasticity in the pathway. However, little was known about the mechanisms underlying the process. In order to address this issue, both dopamine and serotonin as monoaminergic neurotransmitters were involved in this study, since they were crucial factors in pathological basis of depressive disorder. Local field potentials (LFPs) were recorded simultaneously at both vCA1 and mPFC regions under anesthesia, before and after the injection of dopamine D1 receptor antagonist and 5-HT1A receptor agonist, respectively. The results showed that the blockage of D1 receptor could lead to depression-like decrement on theta phase coupling. In addition, the activation of 5-HT1A receptor enhanced vCA1–mPFC coupling on gamma oscillations, and attenuated CA1 theta-fast gamma cross frequency coupling. These data suggest that the theta phase coupling between vCA1 and mPFC may be modulated by dopamine system that is an underlying mechanism of the cognitive dysfunction in depression. Besides, the serotonergic system is probably involved in the regulation of gamma oscillations coupling in vCA1–mPFC network.

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Abbreviations

CFC:

Cross frequency coupling

CMI:

Conditional mutual information

CUS:

Chronic unpredictable stresses

DA:

Dopamine

fEPSP:

Field excitatory postsynaptic potential

EMA:

Evolution map approach

LFP:

Local field potential

LTP:

Long term potentiation

mPFC:

Medial prefrontal cortex

PAC:

Phase-amplitude coupling

PAC_PLV:

Phase-amplitude coupling-phase locking value

PLV:

Phase locking value

vCA1:

Ventral hippocampal CA1

5-HT:

Serotonin

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Acknowledgments

This work was supported by Grants from the National Natural Science Foundation of China (11232005, 31171053), and 111 Project (B08011).

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    Authors and Affiliations

    1. College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, 300071, People’s Republic of China

      Xiaxia Xu, Chenguang Zheng, Lei An & Tao Zhang

    2. Center for Learning and Memory, The University of Texas at Austin, Austin, TX, USA

      Chenguang Zheng

    3. Institute for Cognitive Neurodynamics, East China University of Science and Technology, Shanghai, 200237, People’s Republic of China

      Rubin Wang

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    Correspondence to Tao Zhang.

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    Xiaxia Xu and Chenguang Zheng have contributed equally to this work.

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    Xu, X., Zheng, C., An, L. et al. Effects of Dopamine and Serotonin Systems on Modulating Neural Oscillations in Hippocampus-Prefrontal Cortex Pathway in Rats. Brain Topogr 29, 539–551 (2016). https://doi.org/10.1007/s10548-016-0485-3

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