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Brain Topography

, Volume 25, Issue 3, pp 332–344 | Cite as

Behavioural Treatment Increases Activity in the Cognitive Neuronal Networks in Children with Attention Deficit/Hyperactivity Disorder

  • Michael Siniatchkin
  • Nora Glatthaar
  • Gabriele Gerber von Müller
  • Alexander Prehn-Kristensen
  • Stephan Wolff
  • Silja Knöchel
  • Elisabeth Steinmann
  • Anna Sotnikova
  • Ulrich Stephani
  • Franz Petermann
  • Wolf-Dieter Gerber
Original Paper

Abstract

Response cost and token approach (RCT) within the scope of a summer camp training is an effective treatment program for attention deficit hyperactivity disorder (ADHD). It is likely that intensive RCT training influences networks responsible for ADHD symptoms. Functional magnetic resonance imaging (fMRI) was carried out in 12 children with ADHD before and after the RCT program and in 12 healthy control children twice. For fMRI, a Go/No-go paradigm was used to investigate the influence of RCT training on attention and impulsivity. The No-go condition revealed only weak activation in the dorsal part of the anterior cingulate cortex (ACC), parietal and dorsolateral prefrontal cortex (DLPFC) before the training in children with ADHD compared to healthy children. However, this activation in these brain regions was significantly more pronounced after the training. This increase in hemodynamic response cannot be attributed merely to repetition of the measurement since the effect was not observed in healthy children. The increase in hemodynamic response in the ACC and right DLPFC was significantly associated with a reduction in response time variability and clinical symptoms in ADHD patients. After the RCT training, the children with ADHD demonstrated more pronounced activation of cortical structures which are typically related to response monitoring and self-control. It seems likely that children with ADHD learned more cognitive control in a continuous performance task as was revealed by both neuropsychological outcome and fMRI.

Keywords

Attention deficit/hyperactivity disorder (ADHD) Behavioral treatment fMRI Go/No-go Ultimatum game Anterior cingulate 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Michael Siniatchkin
    • 1
    • 2
  • Nora Glatthaar
    • 2
  • Gabriele Gerber von Müller
    • 3
  • Alexander Prehn-Kristensen
    • 4
  • Stephan Wolff
    • 5
  • Silja Knöchel
    • 4
  • Elisabeth Steinmann
    • 2
  • Anna Sotnikova
    • 7
  • Ulrich Stephani
    • 2
  • Franz Petermann
    • 6
  • Wolf-Dieter Gerber
    • 3
  1. 1.Clinic for Child and Adolescents PsychiatryGoethe-UniversityFrankfurtGermany
  2. 2.Department of NeuropediatricPediatric Hospital, Christian-Albrechts-UniversityKielGermany
  3. 3.Institute of Medical PsychologyChristian-Albrechts-UniversityKielGermany
  4. 4.Center for Integrative Psychiatry, Department of Child and Adolescent Psychiatry and PsychotherapyChristian-Albrechts-UniversityKielGermany
  5. 5.Department of NeuroradiologyChristian-Albrechts-UniversityKielGermany
  6. 6.Department of Clinical and Rehabilitation PsychologyUniversity of BremenBremenGermany
  7. 7.Clinic for Child and Adolescents PsychiatryPhilipps-UniversityMarburgGermany

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