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Brain Topography

, Volume 24, Issue 2, pp 164–182 | Cite as

Electrophysiological Explorations of the Cause and Effect of Inhibition of Return in a Cue–Target Paradigm

  • Yin Tian
  • Raymond M. Klein
  • Jason Satel
  • Peng Xu
  • Dezhong Yao
Original Paper

Abstract

Facilitation and inhibition of return (IOR) are, respectively, faster and slower responses to a peripherally cued target. In a spatially uninformative peripheral cueing task, facilitation is normally observed when the interval between the cue and target stimulus, the stimulus onset asynchrony (SOA), is shorter than 250 ms, while IOR is normally observed when an SOA greater than 250 ms is used. Since Posner and Cohen’s (Attention and performance X, 1984) seminal study, IOR has become an actively investigated component of orienting. In this study, using ERPs and the source localization algorithm, LORETA, we seek to examine the brain mechanisms involved in IOR by localizing the different stages of processing after the appearance of a cue that captures attention exogenously. Unlike previous ERP investigations of IOR, this study analyzes the neural activity (via EEG) produced in response to the cue, prior to the appearance of the target. Neural activations were approximately divided into three stages. In the early stage (110–240 ms), involved activations are in the prefrontal cortex, the bilateral intraparietal cortex, and the contralateral occipito-temporal cortex. In the middle stage (240–350 ms), activations are primarily found in the frontal cortex and the parietal cortex. In the late stage (350–650 ms), the main activations are in the occipito-parietal cortex, but unlike in the early stage, the activation areas have shifted to the hemisphere ipsilateral to the cued location. These findings indicate that IOR is related to both attentional and motor response processes and suggest that the time course of initial facilitation and IOR is concurrent and mediated by two neural networks. Building upon our results, electrophysiological, electroencephalographic, and behavioral results in the literature and extending previous spatial theories of IOR, we propose here a spatio-temporal theory of IOR based upon post-cue dynamics.

Keywords

Event-related potentials (ERPs) Facilitation Inhibition of return (IOR) Low-resolution electromagnetic tomography (LORETA) Spatially uninformative peripheral cue (SUPC) 

Notes

Acknowledgments

We would like to thank Zhiguo Wang for his help in preparing this manuscript, and also thank Dr. Juan Lupiáñez for his many constructive comments. Funding: This work was supported by the National Nature Science Foundation of China (Grant Numbers 60736029, 60701015), the 863 Project 2009AA02Z301, and the PCSIRT project. Yin Tian was also supported by CPSF (No.20100481379) and PSF of UESTC (No.20100013).

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengDuChina
  2. 2.Department of PsychologyDalhousie UniversityHalifaxCanada
  3. 3.College of Bio-informationChongQing University of Posts and TelecommunicationsChongQingChina

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