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Brain Topography

, 22:215 | Cite as

Integrating TMS with EEG: How and What For?

  • Gregor Thut
  • Alvaro Pascual-Leone
Editorial

Transcranial magnetic stimulation (TMS) is a unique tool that utilizes magnetic fluxes to noninvasively stimulate the human cortex. Introduced in 1985 (Barker et al. 1985), it has developed into a powerful research device by virtue of its capacity to stimulate the brain with a relatively good spatial and temporal selectivity (Walsh and Cowey 2000), without the pain associated with transcranial electrical stimulation (TES), and with an excellent safety profile if appropriate guidelines are followed (Rossi et al. 2009). Guided by studies using brain imaging (e.g. functional MRI) that deliver evidence correlating brain activity with specific behaviors, TMS has been employed to induce transient “virtual lesions” in humans under controlled conditions, providing causal evidence linking activity in specific brain areas with behavior (Walsh and Pascual-Leone 2003). TMS is also being actively studied as a therapeutic technique for certain neuropsychiatric conditions (e.g. depression) via...

References

  1. Barker AT, Jalinous R, Freeston IL (1985) Noninvasive magnetic stimulation of human motor cortex. Lancet 2:1106–1107CrossRefGoogle Scholar
  2. Bestmann S (2008) The physiological basis of transcranial magnetic stimulation. Trends Cogn Sci 12:81–83CrossRefPubMedGoogle Scholar
  3. Bestmann S, Ruff CC, Blankenburg F, Weiskopf N, Driver J, Rothwell JC (2008) Mapping causal interregional inXuences with concurrent TMS–fMRI. Exp Brain Res 191:383–402CrossRefPubMedGoogle Scholar
  4. Brodbeck V, Thut G, Spinelli L, Romei V, Tyrand R, Michel CM, Seeck M (2009) Effects of repetitive Transcranial Magnetic Stimulation on spike pattern and topography in patients with focal epilepsy. Brain Topogr. doi: 10.1007/s10548-009-0125-2
  5. Driver J, Blankenburg F, Bestmann S, Vanduffel W, Ruff CC (2009) Concurrent brain-stimulation and neuroimaging for studies of cognition. Trends Cogn Sci 13:319–327CrossRefPubMedGoogle Scholar
  6. Fregni F, Pascual-Leone A (2007) Technology insight: noninvasive brain stimulation in neurology-perspectives on the therapeutic potential of rTMS and tDCS. Nat Clin Pract Neurol 3:383–393CrossRefPubMedGoogle Scholar
  7. Ilmoniemi RJ, Kičić D (2009) Methodology for combined TMS and EEG. Brain Topogr. doi: 10.1007/s10548-009-0123-4
  8. Johnson JS, Hamidi M, Postle BR (2009) Using EEG to explore how rTMS produces its effects on behavior. Brain Topogr. doi: 10.1007/s10548-009-0118-1
  9. Miniussi C, Thut G (2009) Combining TMS and EEG offers new prospects in cognitive neuroscience. Brain Topogr. doi: 10.1007/s10548-009-0083-8
  10. Paus T, Sipila PK, Strafella AP (2001) Synchronization of neuronal activity in the human primary motor cortex by transcranial magnetic stimulation: an EEG study. J Neurophysiol 86:1983–1990PubMedGoogle Scholar
  11. Rosanova M, Casali A, Bellina V, Resta F, Mariotti M, Massimini M (2009) Natural frequencies of human corticothalamic circuits. J Neurosci 29:7679–7685CrossRefPubMedGoogle Scholar
  12. Rossi S, Hallett M, Rossini PM, Pascual-Leone A, The Safety of TMS Consensus Group (2009) Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol 120:2008–2039CrossRefPubMedGoogle Scholar
  13. Rotenberg A (2009) Prospects for clinical applications of transcranial magnetic stimulation and real-time EEG in epilepsy. Brain Topogr. doi: 10.1007/s10548-009-0116-3
  14. Silvanto J, Pascual-Leone A (2008) State-dependency of transcranial magnetic stimulation. Brain Topogr 21:1–10CrossRefPubMedGoogle Scholar
  15. Thut G, Miniussi C (2009) New insights into rhythmic brain activity from TMS–EEG studies. Trends Cogn Sci 13:182–189CrossRefPubMedGoogle Scholar
  16. Thut G, Pascual-Leone A (2009) A review of combined TMS-EEG studies to characterize lasting effects of repetitive TMS and assess their usefulness in cognitive and clinical neuroscience. Brain Topogr. doi: 10.1007/s10548-009-0115-4
  17. Walsh V, Cowey A (2000) Transcranial magnetic stimulation and cognitive neuroscience. Nat Rev Neurosci 1:73–79CrossRefPubMedGoogle Scholar
  18. Walsh V, Pascual-Leone A (2003) Transcranial magnetic stimulation: a neurochronometrics of mind. Mit Press, Cambridge, MAGoogle Scholar
  19. Zanon M, Busan P, Monti F, Pizzolato G, Battaglini PP (2009) Cortical connections between dorsal and ventral visual streams in humans: evidence by TMS/EEG co-registration. Brain Topogr. doi: 10.1007/s10548-009-0103-8

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Centre for Cognitive Neuroimaging, Department of PsychologyUniversity of GlasgowGlasgowUK
  2. 2.Berenson-Allen Center for Noninvasive Brain StimulationBeth Israel Deaconess Medical Center, Harvard Medical SchoolBostonUSA

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