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Oxygen in mitochondrial disease: can there be too much of a good thing?

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Journal of Inherited Metabolic Disease

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Funding

PFC is a Wellcome Trust Senior Fellow in Clinical Science (101876/Z/13/Z), and a UK NIHR Senior Investigator, who receives support from the Medical Research Council Mitochondrial Biology Unit (MC_UP_1501/2), the Medical Research Council (UK) Centre for Translational Muscle Disease (G0601943), the Evelyn Trust, and the National Institute for Health Research (NIHR) Biomedical Research Centre based at Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge. V.K.M. is an Investigator of the Howard Hughes Medical Institute. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA

    Vamsi K. Mootha

  2. MRC Mitochondrial Biology Unit & Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK

    Patrick F. Chinnery

Authors
  1. Vamsi K. Mootha
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  2. Patrick F. Chinnery
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Corresponding author

Correspondence to Patrick F. Chinnery.

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Conflicts of interest

VKM is listed as an inventor on a patent application filed by the Massachusetts General Hospital on the use of hypoxia and related methods as a therapy for mitochondrial disorders. PFC reports no conflict of interest.

Additional information

Communicated by: Shamima Rahman

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Mootha, V.K., Chinnery, P.F. Oxygen in mitochondrial disease: can there be too much of a good thing?. J Inherit Metab Dis 41, 761–763 (2018). https://doi.org/10.1007/s10545-018-0210-3

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  • DOI: https://doi.org/10.1007/s10545-018-0210-3

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