Journal of Inherited Metabolic Disease

, Volume 32, Issue 4, pp 481–487 | Cite as

Can we use statins to prevent stroke in Fabry disease?



Fabry disease is a rare, X-linked lysosomal storage disease caused by an inborn deficiency of α-galactosidase A, which results in the progressive accumulation of globotriaosylceramide and other neutral glycolipids in a range of cells and tissues. In association with the renal and cardiac insufficiency, cerebrovascular complications can result in the death of the patients. Several mechanisms causing vascular damage that leads to the development of deep-white matter lesions have been described. Recent clinical trials strongly suggest that statins protect against stroke by neuroprotective properties or pleiotropic effects. Aim: To evaluate evidence and potential beneficial effects of statins in the vasculopathy of Fabry disease.


Nitric Oxide Simvastatin Homocysteine Tissue Factor Fabry Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



enzyme replacement therapy


Fabry disease




α-galactosidase A


3-hydroxy-3-methylglutaryl coenzyme A


intercellular adhesion molecule-1


intima-media thickness


nitric oxide synthase


plasminogen activator inhibitor-1


vascular cell adhesion molecule-1


white-matter lesion


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.Neurology ServiceJuan A Fernandez HospitalBuenos AiresArgentina

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