Advertisement

Journal of Inherited Metabolic Disease

, Volume 30, Issue 2, pp 267–267 | Cite as

Secondary alteration of the transferrin isoelectric focusing pattern in a case of bacterial meningitis

  • E. Quintana
  • S. Gala
  • A. García-Cazorla
  • R. Montero
  • C. Muñoz-Almagro
  • M. A. Vilaseca
  • P. Briones
  • R. Artuch
Short Report

Summary

Congenital disorders of glycosylation (CDG) are a group of inherited defects in the synthesis and processing of the linked glycans of glycoproteins and other glycoconjugates. The phenotypic spectrum presents wide variability, and clinical diagnosis is not reliable in most cases. Isoelectric focusing (IEF) of serum transferrin is widely used as a tool to detect CDG. We describe a paediatric patient presenting an altered serum transferrin pattern due to a secondary disorder of glycosylation caused by pneumococcal meningitis (Streptococcus pneumoniae, serotype 19A). During admission, brain CT scan and MRI showed acute ischaemic lesions in brain frontotemporal parenchyma, and enlarged subarachnoidal spaces in the frontal area resembling a chronic injury. This led us to screen for inborn errors of metabolism potentially associated with these findings (homocystinuria, glutaric aciduria, CDG syndromes). Biochemical studies for the screening of these inborn errors of metabolism were normal except for sialotransferrin isoelectric focusing, which showed a type 2 pattern. However, 16 days later, together with the remission of the meningitis process, the sialotransferrin pattern had normalized. The apolipoprotein C-III (an O-glycoprotein) profile was normal in all samples analysed. In conclusion, infectious events should be ruled out in the differential diagnosis of CDG syndromes. Furthermore, our findings highlight the possibility that the type 2 IEF pattern of serum sialotransferrin detected in some patients with neonatal death due to organ failure and septic events might be secondary to the infectious process.

Keywords

Meningitis Bacterial Meningitis Streptococcus Pneumoniae Inborn Error Pneumococcal Meningitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

10545_2007_ESM_530.pdf (201 kb)
Secondary alteration of the transferrin isoelectric focusing pattern in a case of bacterial meningitis

Copyright information

© SSIEM and Springer 2007

Authors and Affiliations

  • E. Quintana
    • 1
  • S. Gala
    • 2
  • A. García-Cazorla
    • 3
  • R. Montero
    • 4
  • C. Muñoz-Almagro
    • 5
  • M. A. Vilaseca
    • 4
  • P. Briones
    • 1
    • 6
  • R. Artuch
    • 4
  1. 1.Institut de Bioquímica ClínicaHospital ClínicBarcelonaSpain
  2. 2.Pediatrics DepartmentHospital Sant Joan de DéuBarcelonaSpain
  3. 3.Neuropediatrics DepartmentHospital Sant Joan de DéuBarcelonaSpain
  4. 4.Clinical Biochemistry DepartmentHospital Sant Joan de DéuBarcelonaSpain
  5. 5.Microbiology DepartmentHospital Sant Joan de DéuBarcelonaSpain
  6. 6.Consejo Superior de Investigaciones CientíficasBarcelonaSpain

Personalised recommendations