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Severe hyperhomocysteinaemia and 5-oxoprolinuria secondary to antiproliferative and antimicrobial drug treatment

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Journal of Inherited Metabolic Disease

Summary

A hitherto healthy 7-year-old girl underwent antiproliferative and antibiotic treatment owing to the diagnosis of T-cell lymphoma and concomitant bacterial infection. She developed an encephalopathic crisis associated with metabolic acidosis, hyponatraemia and severe hyperhomocysteinaemia and 5-oxoprolinuria. Laboratory tests normalized completely after recovery. Primary defects in glutathione metabolism could be excluded.

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Authors and Affiliations

  1. Clinic for General Pediatrics, University Children’s Hospital, Moorenstrasse 5, D-40225, Düsseldorf, Germany

    B. Schwahn & E. Mayatepek

  2. Clinic for Pediatric Oncology, Hematology and Immunology, University Children’s Hospital, Düsseldorf, Germany

    G. Kameda & R. Wessalowski

Authors
  1. B. Schwahn
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  2. G. Kameda
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  3. R. Wessalowski
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  4. E. Mayatepek
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Correspondence to B. Schwahn.

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Schwahn, B., Kameda, G., Wessalowski, R. et al. Severe hyperhomocysteinaemia and 5-oxoprolinuria secondary to antiproliferative and antimicrobial drug treatment. J Inherit Metab Dis 28, 99–102 (2005). https://doi.org/10.1007/s10545-005-5084-5

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  • DOI: https://doi.org/10.1007/s10545-005-5084-5

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