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Severe hyperhomocysteinaemia and 5-oxoprolinuria secondary to antiproliferative and antimicrobial drug treatment

  • B. Schwahn
  • G. Kameda
  • R. Wessalowski
  • E. Mayatepek
Short Report

Summary

A hitherto healthy 7-year-old girl underwent antiproliferative and antibiotic treatment owing to the diagnosis of T-cell lymphoma and concomitant bacterial infection. She developed an encephalopathic crisis associated with metabolic acidosis, hyponatraemia and severe hyperhomocysteinaemia and 5-oxoprolinuria. Laboratory tests normalized completely after recovery. Primary defects in glutathione metabolism could be excluded.

Keywords

Public Health Internal Medicine Lymphoma Glutathione Laboratory Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© SSIEM and Springer 2005

Authors and Affiliations

  • B. Schwahn
    • 1
  • G. Kameda
    • 2
  • R. Wessalowski
    • 2
  • E. Mayatepek
    • 1
  1. 1.Clinic for General PediatricsUniversity Children’s HospitalDüsseldorfGermany
  2. 2.Clinic for Pediatric Oncology, Hematology and ImmunologyUniversity Children’s HospitalDüsseldorfGermany

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