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NCI Alliance for Nanotechnology in Cancer – from academic research to clinical interventions

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Abstract

The National Cancer Institute (NCI) of National Institutes of Health has funded and operated the NCI Alliance for Nanotechnology in Cancer - a large multi-disciplinary program which leverages research at the intersection of molecular biology, oncology, physics, chemistry, and engineering to develop innovative cancer interventions. The program has demonstrated that convergence of several scientific disciplines catalyzes innovation and progress in cancer nanotechnology and advances its clinical translation. This paper takes a look at last thirteen years of the Alliance program operations and delineates its outcomes, successes, and outlook for the future.

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References

  • S. Chapman, N.J. Panaro, G.W. Hinkal, S.S. Hook, U. Prabhakar, K. Ptak, D. Farrell, P. Grodzinski, Kindling translational cancer nanotechnology research. Nanomedicine (London) 7, 321–325 (2012)

    Article  Google Scholar 

  • F. Currell, M. Bellringer, Cancer nanotechnology startup challenge: A new way to realize the fruits of innovation. Cancer Nanotechnology 7(2) (2016)

  • A. Dickherber, S.A. Morris, P. Grodzinski, NCI investment in nanotechnology: Achievements and challenges for the future. Wiley Interdiscip Rev Nanomed Nanobiotechnol 7, 251 (2015)

    Article  Google Scholar 

  • D. Farrell, J. Alper, K. Ptak, N.J. Panaro, P. Grodzinski, A.D. Barker, Recent advances from the National Cancer Institute Alliance for nanotechnology in Cancer. ACS Nano 4, 589 (2010)

    Article  Google Scholar 

  • D. Farrell, K. Ptak, N.J. Panaro, P. Grodzinski, Nanotechnology-based cancer therapeutics-promise and challenge-lessons learned through the NCI Alliance for nanotechnology in Cancer. Pharm. Res. 28, 273–278 (2011)

    Article  Google Scholar 

  • M. Ferrari, Cancer nanotechnology: Opportunities and challenges. Nat. Rev. Cancer 5, 161 (2005)

    Article  Google Scholar 

  • P. Grodzinski, D. Farrell, Future opportunities in cancer nanotechnology--NCI strategic workshop report. Cancer Res. 74, 1307 (2014)

    Article  Google Scholar 

  • C.M. Hartshorn, M.S. Bradbury, G.M. Lanza, A.E. Nel, J. Rao, A.Z. Wang, U.B. Wiesner, L. Yang, P. Grodzinski, Nanotechnology strategies to advance outcomes in clinical Cancer care. ACS Nano 12, 24 (2018)

    Article  Google Scholar 

  • B.I. Hutchins, X. Yuan, J.M. Anderson, G.M. Santangelo, Relative citation ratio (RCR): A new metric that uses citation rates to measure influence at the article level. PLoS Biol. 14, e1002541 (2016)

    Article  Google Scholar 

  • T. Lenoir, P. Herron, The NCI and the takeoff of nanomedicine. J Nanomedine Biotherapeutic Discovery 5, 2 (2015)

    Google Scholar 

  • L.A. Nagahara, J.S. Lee, L.K. Molnar, N.J. Panaro, D. Farrell, K. Ptak, J. Alper, P. Grodzinski, Strategic workshops on cancer nanotechnology. Cancer Res. 70, 4265 (2010)

    Article  Google Scholar 

  • U. Prabhakar, D.C. Blakey, H. Maeda, R.K. Jain, E.M. Sevick-Muraca, W. Zamboni, O.C. Farokhzad, S.T. Barry, A. Gabizon, P. Grodzinski, Challenges and key considerations of the enhanced permeability and retention effect (EPR) for nanomedicine drug delivery in oncology. Cancer Res. 73, 2412 (2013)

    Article  Google Scholar 

  • R. Truman, C.J. Locke, Gazelles, unicorns, and dragons battle cancer through the nanotechnology startup challenge. Cancer Nanotechnol 7, 4 (2016)

    Article  Google Scholar 

  • W.C. Zamboni, V. Torchilin, A.K. Patri, J. Hrkach, S. Stern, R. Lee, A. Nel, N.J. Panaro, P. Grodzinski, Best practices in cancer nanotechnology: Perspective from NCI nanotechnology Alliance. Clin. Cancer Res. 18, 3229 (2012)

    Article  Google Scholar 

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Authors and Affiliations

  1. Nanodelivery Systems and Devices Branch, Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA

    Piotr Grodzinski, Christina H. Liu, Christopher M. Hartshorn & Luisa M. Russell

  2. NIH Office of Strategic Coordination, National Institutes of Health, Bethesda, MD, 20893, USA

    Stephanie A. Morris

Authors
  1. Piotr Grodzinski
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  2. Christina H. Liu
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  3. Christopher M. Hartshorn
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  4. Stephanie A. Morris
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  5. Luisa M. Russell
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Correspondence to Piotr Grodzinski.

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Grodzinski, P., Liu, C., Hartshorn, C. et al. NCI Alliance for Nanotechnology in Cancer – from academic research to clinical interventions. Biomed Microdevices 21, 32 (2019). https://doi.org/10.1007/s10544-019-0360-6

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  • DOI: https://doi.org/10.1007/s10544-019-0360-6

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