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Polymeric check valve with an elevated pedestal for precise cracking pressure in a glaucoma drainage device

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Abstract

This paper presents the design, fabrication, and characterization of a polymeric micro check valve for a glaucoma drainage device (GDD) featuring the precise regulation of intraocular pressure (IOP) and effective aqueous humor turnover (AHT). The pedestal, slightly elevated by selective coating of a parylene C film, induces pre-stress in the thin valve membrane, which enhances the predictability of the cracking pressure of the GDD. The proposed GDD comprises a cannula and a normally closed polymeric micro check valve, which are made of PDMS, a biocompatible polymer, with three layers: top (cover), intermediate (thin valve membrane), and bottom (base plate). A feedback channel, located between the top and intermediate layers, prevents reverse flow by feeding the pressure of the outlet channel back to the thin valve membrane. To achieve a precise cracking pressure and sufficient drainage of humor for humans, the thicknesses of the valve membrane and parylene C film are designed to be 58 μm and 1 μm, respectively, which are confirmed using a COMSOL simulation. The experimental results show that the cracking pressure of the fabricated GDD lies within the range of normal IOP (1.33–2.67 kPa). The forward flow rate (drainage rate), 4.3 ± 0.9 μL/min at 2.5 kPa, is adequate to accommodate the rate of AHT in a normal human eye (2.4 ± 0.6 μL/min). The reverse flow was not observed when a hydrostatic pressure of up to 4 kPa was applied to the outlet and the feedback channel.

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Acknowledgments

This work was supported partially by BioNano Health-Guard Research Center funded by the Ministry of Science, ICT & Future Planning (MSIP) of Korea as “Global Frontier Project” (Grant Number H-GUARD_ERND2013M3A6B2078957) and by the “Basic Research Projects in High-tech Industrial Technology” through a grant provided by GIST in 2015.

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Authors and Affiliations

  1. Department of Medical System Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea

    Chang-Ju Park, Dong-Seong Yang, Jung-Joon Cha & Jong-Hyun Lee

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  1. Chang-Ju Park
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  2. Dong-Seong Yang
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  3. Jung-Joon Cha
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  4. Jong-Hyun Lee
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Correspondence to Jong-Hyun Lee.

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Park, CJ., Yang, DS., Cha, JJ. et al. Polymeric check valve with an elevated pedestal for precise cracking pressure in a glaucoma drainage device. Biomed Microdevices 18, 20 (2016). https://doi.org/10.1007/s10544-016-0048-0

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  • DOI: https://doi.org/10.1007/s10544-016-0048-0

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