Assessment of navigation control strategy for magnetotactic bacteria in microchannel: toward targeting solid tumors
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This paper presents a Magnetotactic Bacteria (MTB) navigation and aggregation technique that allows targeting without prior knowledge of the exact architecture of the vessels network. The MTB’s active motility combined with magnetotaxism (their ability to swim following the magnetic field direction) offer new possibilities for the delivery of drugs to tumors. Many tumor microenvironment parameters such as the malformed angiogenesis capillaries, the heterogeneous blood flow, and the high interstitial pressure affect the delivery of blood-borne drugs to the tumor. Microorganisms used as microcarriers might be helpful in bypassing these limitations while helping to uniformly distribute the drug in the targeted area. Since the angiogenesis network of blood vessels that the tumors recruit is highly disorganized and unpredictable, the magnetic control method adopted account for these parameters to achieve targeting. We demonstrate the effectiveness of the proposed method using a microchannel network offering a complex pattern considered as a worst-case navigation situation. Besides targeted drug delivery to tumor sites using bacterial carrier, aggregation of microorganisms is required for micromanipulation and microassembly.
KeywordsMagnetotactic bacteria Magnetic devices Micro-robotics Bacterial aggregation Directional control
This project is supported in part by École Polytechnique Research Chair in Nanorobotics, a Discovery grant from the Natural Sciences and Engineering Research Council of Canada (NSERC), and US grant Number R21EB007506 from the National Institute Of Biomedical Imaging And Bioengineering. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Biomedical Imaging And Bioengineering or the National Institutes of Health (NIH). The authors would like to thank Mahmood Mohammadi from the NanoRobotics Laboratory, Polytechnique of Montréal for his valuable help with MC-1 magnetotactic bacteria, and Ayman Baatour for his help in conducting some experiments.
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