Patterning of microspheres and microbubbles in an acoustic tweezers
- 661 Downloads
We describe the construction of an ultrasonic device capable of micro-patterning a range of microscopic particles for bioengineering applications such as targeted drug delivery. The device is formed from seven ultrasonic transducers positioned around a heptagonal cavity. By exciting two or three transducers simultaneously, lines or hexagonal shapes can be formed with microspheres, emulsions and microbubbles. Furthermore, phase control of the transducers allows patterning at any desired position in a controlled manner. The paper discusses in detail direct positioning of functionalised microspheres, emulsions and microbubbles. With the advantages of miniaturization, rapid and simple fabrication, ultrasonic tweezers is a potentially useful tool in many biomedical applications.
KeywordsAcoustic radiation pressure Particle patterning 2D particle manipulation Sonotweezers
The authors thank the Sonotweezers project partners at the Universities of Bristol, Southampton and Dundee for their support and assistance in this research.
- A.L. Bernassau, O. Chun-Kiat, M. Yong, P.G.A. Macpherson, C.R.P. Courtney, M. Riehle, B.W. Drinkwater, D.R.S. Cumming, Two-dimensional manipulation of micro particles by acoustic radiation pressure in a heptagon cell. IEEE Trans Ultrason Ferroelectrics Freq Contr 58(10), 2132–2138 (2011)CrossRefGoogle Scholar
- C.R.P. Courtney, C.K. Ong, B.W. Drinkwater, A.L. Bernassau, P.D. Wilcox, D.R.S. Cumming, Manipulation of particles in two dimensions using phase controllable ultrasonic standing waves. Proceedings of the Royal Society of London Series A: Mathematical, Physical and Engineering Sciences. 468(2138), 337–360 (2012)Google Scholar
- A.L. Klibanov, M.S. Hughes, J.N. Marsh, C.S. Hall, J.G. Miller, J.H. Wible, G.H. Brandenburger, Targeting of ultrasound contrast material. An in vitro feasibility study. Acta Radiol Suppl 412, 113–120 (1997)Google Scholar
- T. Kozuka, T. Tuziuti, H. Mitome, T. Fukuda, Non-contact micromanipulation using an ultrasonic standing wave field. IEEE International Conference on Micro Electro Mechanical Systems - MEMS, pp. 435–440 (1996)Google Scholar
- D.D. Lasic, D. Papahadjopoulos (Eds.), Medical applications of liposomes. Elsevier (1998)Google Scholar
- S.M. van der Meer, M. Versluis, D. Lohse, C.T. Chin, A. Bouakaz, N. de Jong, The resonance frequency of SonoVue & trade; as observed by high-speed optical imaging. IEEE Ultrason Symp 341, 343–345 (2004)Google Scholar
- Y. Yamakoshi, M. Koganezawa, Bubble manipulation by self organization of bubbles inside ultrasonic wave. Jpn J Appl Phys 44(6B) (2004)Google Scholar