Advertisement

Biomedical Microdevices

, Volume 15, Issue 1, pp 63–72 | Cite as

Telemetry capsule for measuring contractile motion in the small intestine

  • S. H. Arman Woo
  • Z. Mohy-Ud-Din
  • J. H. Cho
Article

Abstract

The aim of this study was to develop a capsule which can measure contractions in the small intestine. Currently available methods cause discomfort to the patient while taking measurements; with the development of a telemetry capsule that can measure contractions, patients can avoid pain and continue with ordinary activities while the information is automatically collected from the external receiver. In order to develop the contraction force measuring capsule, various types of silicone transducers were designed and implemented to measure the contraction pressure in the small intestine. The minimum resolution of the implemented transducer was 0.05 mbar, which was small enough to measure contractions. The transducer was assembled with telemetry modules and packaged as a capsule (Φ13 × L25 mm) that had a similar size to a commercial capsule endoscope. In order to verify the function of the capsule, in vitro experiments were conducted and contractile motion was measured as 16.6 cycles per minute (CPM).

Keywords

Telemetry Capsule Contraction pressure Contractile motion Silicone transducer 

Notes

Acknowledgment

This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (Number:A092106). Also This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology(2010–0025322)

References

  1. 1.
    http://www.smartpillcorp.com/ , available at May, 2010
  2. 2.
    http://www.gi.org/patients/ibsrelief/ , available at May, 2010
  3. 3.
    T. Tomomasa, A. Morikawa, R.H. Sandler, H.A. Mansy, H. Koneko, T. Masahiko, P.E. Hyman, Z. Itoh, Gastrointestinal sounds and migrating motor complex in fasted humans. Am. J. Gastroenterol. 94, 374–381 (1994)CrossRefGoogle Scholar
  4. 4.
    C.H. Lee, W.T. Lee, S.L. Chen, T.M. Chen, H.J. Wang, C. Yieh, T.D. Chou, Evaluation of gastric emptying with radio-opaque marker in major burned patients. J. Med. Sci. 23, 151–154 (2003)Google Scholar
  5. 5.
    N.M. Prakash, M.C. Brown, F.A. Spelman, J.A. Nelson, P. Read, M.M. Heitkemper, R.W. Tobin, C.E. Pope, "Magnetic field goniometry: a new method to measure the frequency of stomach contraction,". Dig. Dis. Sci. 44, 1735–1740 (1999)CrossRefGoogle Scholar
  6. 6.
    W. Andra, H. Danan, W. Kirmsse, H.H. Kramer, P. Saupe, R. Schmieg, M.E. Bellemann, A novel method for real-time magnetic marker monitoring in the gastrointestinal tract. Phys. Med. Biol. 45, 3081–3093 (2000)CrossRefGoogle Scholar
  7. 7.
    B. Wedmann, R.J. Adamek, M. Wegener, Ultrasound detection of gastric antrum motility evaluating a simple semiquantitative method. Ultraschall Med. 16, 137–142 (1995)Google Scholar
  8. 8.
    C.K. Huang, G.H. Chen, H.M. Nain, J.R. Wahn, Y.P. Cheng, C.S. Chang, J.H. Liu, K.S. Ho, Use of real-time ultrasound for detection gastric motility. Zhonghua Yixue Zazhi 55, 137–142 (1995)Google Scholar
  9. 9.
    National Digestive Diseases Information Clearinghouse (NDDIC), http://digestive.niddk.nih.gov/
  10. 10.
    S. BagcC, N. Ercin, Z. Yesilova, A. Ozcan, B. Degertekin, K. Dagalp, Levels of serologic markers of celiac disease in patients with reflux esophagitis. World J. Gastroenterol. 12, 6707–6710 (2006)Google Scholar
  11. 11.
    R. Moraes, L.A. Cora, M.F. Americo, R.B. Oliveira, O. Baffa, J.R.A. Miranda, Measurement of gastric contraction activity in dogs by means of a cbiosusceptometry. Physiol. Meas. 24, 337–345 (2003)CrossRefGoogle Scholar
  12. 12.
    A. Moglia, A. Menciassi, M.O. Schurr, P. Dario, Wireless capsule endoscopy: from diagnostic devices to multipurpose robotic systems. Biomed. Microdevices 9(2), 235–243 (2007)CrossRefGoogle Scholar
  13. 13.
    K.W. Yoon, S.H. Woo, J.H. Lee, Y.H. Yoon, M.K. Kim, C.H. Won, H.C. Choi, J.H. Cho, Telemetry capsule for pressure monitoring in the gastrointestinal tract. IEICE Transection E89-A, 1699–1700 (2006)CrossRefGoogle Scholar
  14. 14.
    W.X. Wang, G.Z. Yan, F. Sun, P.P. Jiang, W.Q. Zhang, G.F. Zhang, A non-invasive method for gastrointestinal parameter monitoring. World J. Gastroenterol. 11, 521–524 (2005)Google Scholar
  15. 15.
    Y. I. Kim, G. H. Lee, S. H. Park, B. K. Kim, J. O. Park, J. H. Cho “Pressure Monitoring System in Gastro-Intestinal Tract,” Proceedings of the 2005 IEEE International Conference on Robotics and Automation, , Barcelona, Spain, pp.1321–1326, 2005Google Scholar
  16. 16.
    Jiang Pingping Yan Guozheng, Ding Guoqing, Wung wenxing “Researches on a Telemetry System for Gastrointestinal Motility Monitoring,” 2003 International Symposium on Micromechtronics and Human Science, Shanghai, China, pp.299–302, 2003Google Scholar
  17. 17.
    http://www.smartpillcorp.com/, USA, available at March, 2010
  18. 18.
    D. Cassilly, S. Kantor, L.C. Knight, A.H. Maurer, R.S. Fisher, J. Semler, H.P. Parkman, Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy. Neurogastroenterol. Motil. 20, 311–319 (2008)CrossRefGoogle Scholar
  19. 19.
    W.Q. Zhang, G.Z. Yan, D.D. Ye, C.W. Chen, Simultaneous assessment of the intraluminal pressure and transit time of the colon using a telemetry technique. Physiol. Meas. 28, 141–148 (2007)CrossRefGoogle Scholar
  20. 20.
    E.A. Monasterio, Latex allergy in adults with spinal cord injury: a pilot investigation. J. Spinal Cord Med. 23, 6–9 (2000)Google Scholar
  21. 21.
    A.S. MacDonald, S.K.P. Master, E.A. Moffitt, “A comparative study of peripherally inserted silicone catheters for parenteral nutrition,”. Can. Anaesth. Soc. J. 24, 263–269 (1977)CrossRefGoogle Scholar
  22. 22.
    N. Sabbuba et al., The migration of Proteus mirabilis and other urinary tract pathogens over Foley catheters. BJU Int. 89, 55–60 (2002)CrossRefGoogle Scholar
  23. 23.
    C. Gabriel, S. Gabriel, E. Corthout, The dielectric properties of biological tissues: literature survey. Phys. Med. Biol. 41, 2231–2249 (1996)CrossRefGoogle Scholar
  24. 24.
    Compilation of the Dielectric Properties of Body Tissues at RF and Microwave Frequencies, http://www.brooks.af.mil/AFRL/HED/hedr/reports/dielectric/home.html
  25. 25.
    ICNIRP, “Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz),”. Health Phys. 74(4), 494–522 (1998)Google Scholar
  26. 26.
    IEEE Standards IEEE standard for safety levels with respect to human exposure to radio frequency electromagnetic fields, 3 kHz to 300 GHz, 2004Google Scholar
  27. 27.
    ANSI Safety levels with respect to human exposure to raio frequency electromagnetic fields, 300 KHz to 100 GHz, 1982Google Scholar
  28. 28.
    S.I. Kwak, K. Chang, Y.J. Yoon, Small spiral antenna for wideband capsule endoscope system. Electron. Lett. 42(23), 1328–1329 (2006)CrossRefGoogle Scholar
  29. 29.
    H. Fischer, S. Lo, V. Deleon, "Gastrointestinal transit of the wireless endoscopic capsule,". Gastrointest. Endosc. 55, 134 (2002)Google Scholar
  30. 30.
    J.H. Lee, Y.K. Moon, Y.H. Yoon, H.J. Park, C.H. Won, H.C. Choi, J.H. Cho, CPLD based bi-directional wireless capsule endoscopes. IEICE T. Inf. Syst. E90-D(3), 694–697 (2007)CrossRefGoogle Scholar
  31. 31.
    “Evaluating Compliance with FCC Guideline for Human Exposure to Radiofrequency Electromagnetic Fields,” Federal Communication Commission Office Engineering and Technology Supplement 2001Google Scholar
  32. 32.
    C.J. Hanna, S.H. Roth, Combination bronchodilators: antagonism of airway smooth muscle contractions. Inflamm. Res. 9, 18–23 (1979)Google Scholar
  33. 33.
    S.H. Woo, T.W. Kim, J.H. Cho, Stopping mechanism for capsule endoscope using electrical stimulus. Medical Biological Engineering Computing 48, 97–102 (2010)CrossRefGoogle Scholar
  34. 34.
    P. Glass, E. Cheung, M. Sitti, A legged anchoring mechanism for capsule endoscopes using micro patterned adhesives. IEEE Trans Biomed Eng. Vol. 55, 2759–2767 (2008)CrossRefGoogle Scholar
  35. 35.
    J. Worsoe et al., Gastric transit and small intestinal transit time and motility assessed by a magnet tracking system. BMC Gastroenterol. 11, 145 (2011)CrossRefGoogle Scholar
  36. 36.
    M. Simi et al., “Design, Fabrication, and testing of a capsule with hybrid locomotion for gastrointestinal tract exploration,” mechatronics. IEEE/ASME Transactions on 15, 170–180 (2010)CrossRefGoogle Scholar
  37. 37.
    A. Menciassi et al., "Legged locomotion in the gastrointestinal tract," in Intelligent Robots and Systems, 2004. (IROS 2004). Proceedings. 2004 IEEE/RSJ International Conference on 1, 937–942 (2004)Google Scholar
  38. 38.
    S.H. Woo, et al., “Small intestinal model for electrically propelled capsule endoscopy,” Biomedical Engineering Online, vol. 10, 2011Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.BK21 Research Team, College of Rehabilitation ScienceDaegu UniversityDaeguRepublic of Korea
  2. 2.Department of Biomedical EngineeringSir Syed University of Engineering and TechnologyKarachiPakistan
  3. 3.Department of Electronic Engineering and Computer ScienceKyungpook National UniversityDaeguRepublic of Korea

Personalised recommendations