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Biochemistry (Moscow)

, Volume 70, Issue 10, pp 1157–1162 | Cite as

Enhanced Activity of DNA Polymerase Iota in Mouse Brain Cells Is Associated with Aggressiveness

  • L. V. Gening
  • A. A. Kamensky
  • N. G. Levitskaya
  • A. N. Petrochenkov
  • I. I. Poletaeva
  • V. Z. Tarantul
Article

Abstract

Recent studies performed with crude extracts of mouse tissues showed that the activity of DNA-polymerase iota (Pol ι) can be detected only in brain and testis extracts. To assess whether the activity of Pol ι is associated with animal behavior, we determined Pol ι activity in brain extracts of mice of two lines sharply differing in aggressiveness (RSB and RLB). We found that Pol ι activity in the mice with aggressive behavior was three times higher than in the less aggressive mice. The possible relationship between the activity of Pol ι and animal behavior is discussed.

Key words

DNA-polymerase iota aggressiveness animal behavior brain genome stability 

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Copyright information

© MAIK "Nauka/Interperiodica" 2005

Authors and Affiliations

  • L. V. Gening
    • 1
  • A. A. Kamensky
    • 2
  • N. G. Levitskaya
    • 2
  • A. N. Petrochenkov
    • 1
  • I. I. Poletaeva
    • 2
  • V. Z. Tarantul
    • 1
  1. 1.Institute of Molecular GeneticsRussian Academy of SciencesMoscowRussia
  2. 2.Biological FacultyLomonosov Moscow State UniversityMoscowRussia

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