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Spectral Study of Interactions of 4,8,4′-Trimethylpsoralen and 4,4′-Dimethylangelicin Dyes with DNA

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Abstract

Absorption and fluorescence spectra for six new synthetic dyes of 4,8,4′-trimethylpsoralen and 4,4′-dimethylangelicin derivatives containing various terminal substituents at 5′-position have been investigated in different environments using a wide range of the DNA/ligand concentrations. Various spectral and binding characteristics of the DNA-ligand systems have been determined. General principles characterizing mechanisms responsible for changes in the fluorescent properties of nucleotide-specific dyes have been proposed; they take into consideration chemical structure of the dyes, properties of the environment, and degree of sorption on substrate.

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Authors and Affiliations

  1. Mendeleyev Russian Research Institute for Metrology, Moskovsky pr. 19, 190005, St. Petersburg, Russia

    V. S. Sibirtsev

  2. Mendeleyev University of Chemical Technology of Russia, Miusskaya pl. 9, 125047, Moscow, Russia

    A. Yu. Tolmachev & V. F. Traven

  3. St. Petersburg State Technological Institute, Zagorodnyi pr. 49, 190013, St. Petersburg, Russia

    M. V. Kovaleva & A. V. Garabadzhiu

Authors
  1. V. S. Sibirtsev
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  2. A. Yu. Tolmachev
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  3. M. V. Kovaleva
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  4. A. V. Garabadzhiu
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  5. V. F. Traven
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Correspondence to V. S. Sibirtsev.

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__________

Translated from Biokhimiya, Vol. 70, No. 7, 2005, pp. 995–1007.

Original Russian Text Copyright © 2005 by Sibirtsev, Tolmachev, Kovaleva, Garabadzhiu, Traven.

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Sibirtsev, V.S., Tolmachev, A.Y., Kovaleva, M.V. et al. Spectral Study of Interactions of 4,8,4′-Trimethylpsoralen and 4,4′-Dimethylangelicin Dyes with DNA. Biochemistry (Moscow) 70, 822–832 (2005). https://doi.org/10.1007/s10541-005-0190-4

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  • DOI: https://doi.org/10.1007/s10541-005-0190-4

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