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Bioscience Reports

, Volume 27, Issue 1–3, pp 87–104 | Cite as

Mitochondria and Neurodegeneration

  • Lucia Petrozzi
  • Giulia Ricci
  • Noemi J. Giglioli
  • Gabriele Siciliano
  • Michelangelo Mancuso
Original Paper

Abstract

Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question “is mitochondrial dysfunction a necessary step in neurodegeneration?” is still unanswered. In this review, we highlight some of the major neurodegenerative disorders (Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis and Huntington’s disease) and discuss the role of the mitochondria in the pathogenetic cascade leading to neurodegeneration.

Keywords

Mitochondria mtDNA Alzheimer’s disease Parkinson’s disease Amyotrophic lateral sclerosis Huntington’s disease Neurodegeneration 

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Copyright information

© The Biochemical Society 2007

Authors and Affiliations

  • Lucia Petrozzi
    • 1
  • Giulia Ricci
    • 1
  • Noemi J. Giglioli
    • 1
  • Gabriele Siciliano
    • 1
  • Michelangelo Mancuso
    • 1
  1. 1.Department of NeuroscienceUniversity of PisaPisaItaly

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