Advertisement

Bioscience Reports

, Volume 24, Issue 4–5, pp 302–322 | Cite as

Drugs from Emasculated Hormones: The Principle of Syntopic Antagonism

  • James Black
Nobel Lecture
  • 26 Downloads

Abstract

This lecture outlines the early stages in the discovery of adrenaline β-receptor antagonists and of the histamine H2-receptor antagonists. It ends with a brief personal view about future research.

Key words:

β-adrenergic receptor histamine receptor hormone antagonism 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ahlquist, R. P. 1948Am. J. Physiol153586Google Scholar
  2. Ariens, E. J. 1954Archs. Int. Pharmacodyn. Ther9932Google Scholar
  3. Ash, A. S. F., Schild, H. O. 1966Br. J. Pharmacol27427PubMedGoogle Scholar
  4. Black, J. W. 1973Wood, C. J.Simkins, M. A. eds. Int. Symp. on Histamine H2-Receptor AntagonistsSmith Kline and FrenchWelwyn Garden City, UK219Google Scholar
  5. Black, J. W., Crowther, A. F., Shanks, R. G., Smith, L. H., Dornhorst, A. C. 1964Lanceti1080CrossRefGoogle Scholar
  6. Black, J. W., Duncan, W. A. M., Durant, G. J., Ganellin, C. R., Parsons, M. E. 1972Nature236385(London)CrossRefPubMedGoogle Scholar
  7. Black, J. W., Duncan, W. A. M., Shanks, R. G. 1965Br. J. Pharmacol25577PubMedGoogle Scholar
  8. Black, J. W., Fisher, E. W., Smith, A. N. 1958J. Physiol14127PubMedGoogle Scholar
  9. Black, J. W., Jenkinson, D. H., Kenakin, T. P. 1980Eur. J. Pharmacol651CrossRefPubMedGoogle Scholar
  10. Black, J. W., Leff, P. 1983Proc. Roy. Soc. B220141Google Scholar
  11. Black, J. W., Leff, P., Shankley, N. P., Wood, J. 1985aBr. J. Pharmacol84561Google Scholar
  12. Black, J. W., Leff, P., Shankley, N. P. 1985bBr. J. Pharmacol86589Google Scholar
  13. Black, J. W., Stephenson, J. S. 1962Lancetii311CrossRefGoogle Scholar
  14. Cannon, W. B., and Rosenbleuth, A. (1939) in Autonomic Neuroeffector Mechanisms. The Macmillan Co., New YorkGoogle Scholar
  15. Clark, A. J. (1933) in The Mode of Action of Drugs in Cells. Edward Arnold Co., LondonGoogle Scholar
  16. Code, C. F. 1965Fed. Proc24311Google Scholar
  17. Dale, H. H. 1906J. Physiol. London34163Google Scholar
  18. Dornhorst, A. C., Robinson, B. F. 1962Lancetii314CrossRefGoogle Scholar
  19. Edelman, G. M. 1984Ann. Rev. Neurosci7339CrossRefPubMedGoogle Scholar
  20. Folkow, B., Maeger, K., Kahlson, G. 1948Acta Physiol. Scand15264Google Scholar
  21. Ghosh, M. N., Schild, H. O. 1958Br. J. Pharmacol. Chemother1354Google Scholar
  22. Grossman, S. P. (1967) In: Handbook of Physiology 1, Washington, USA, Sect. 6, pp. 287Google Scholar
  23. Hokfelt, T., Millhorn, D., Seroogy, K., Tsuruo, Y., Ceccatelli, S., Lindh, B., Meister, D., Melander,  T., Schalling, M., Bartfai, T., Terenius, L. 1987Experientia43768CrossRefPubMedGoogle Scholar
  24. Kahlson, G., Rosengren, E. 1972Experientia28993CrossRefPubMedGoogle Scholar
  25. Kenakin, T. P., Beek, D. 1980J. Pharmacol. Exp. Ther213406PubMedGoogle Scholar
  26. Konzett, H 1940N. Arch. Exp. Path. Pharmak19727CrossRefGoogle Scholar
  27. Leff, P., Martin, G. R., Morse, J. M. 1985Br. J. Pharmacol85655PubMedGoogle Scholar
  28. Loew, E. R. 1947Physiol. Rev27542Google Scholar
  29. MacIntosh, F. C. 1938Quart. J. Exp. Physiol2887Google Scholar
  30. Moran, N. C., Perkins, M. E. 1958J. Pharmacol. Exp. Ther124223PubMedGoogle Scholar
  31. Parsons, M. E. (1969) Quantitative studies of drug-induced acid gastric secretion. PhD Thesis, University of LondonGoogle Scholar
  32. Powell, C. E., Slater, I. H. 1958J. Pharmac. Exp. Ther122480Google Scholar
  33. Smith, G., Lawson, D. D. 1958Scot. Med. J3346PubMedGoogle Scholar
  34. Sperry, R. W. 1963Proc. Natl. Acad. Sci. USA50703PubMedGoogle Scholar
  35. Stephenson, R. P. 1956Br. J. Pharmacol11379PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • James Black
    • 1
  1. 1.Department of Analytical Pharmacology Rayne InstituteKing’s College School of Medicine & DentistryLondonUK

Personalised recommendations