, Volume 23, Issue 2, pp 185–196 | Cite as

HIV therapeutic possibilities of gold compounds

  • Pascaline N. Fonteh
  • Frankline K. Keter
  • Debra Meyer


Highly active antiretroviral therapy (HAART) has resulted in decreased mortality and morbidity from the acquired immune deficiency syndrome caused by the human immunodeficiency virus (HIV). Drug resistance and toxicity of HAART has led to the search for novel inhibitors of HIV infection. Gold-based compounds have shown promising activity against a wide range of clinical conditions and microorganism infections including HIV-1. A typical example is auranofin which resulted in an elevated CD4+ T-cell count in an HIV patient being treated for psoriatic arthritis. In addition, reports exist on gold-based inhibitors of reverse transcriptase (RT), protease (PR) and viral entry of host cells. These and other characteristics of gold-based HIV drugs are reviewed here.


Gold Inhibitors HIV AIDS 





Acquired immune deficiency syndrome








Tetra-chloro-(bis-(3,5-dimethlypyrazolyl)methane)gold(III) chloride


Chemokine receptor 5


Cluster of differentiation 25


Cluster of differentiation 4


Cluster of differentiation 45


Cluster of differentiation 8

CEM, MT-4, OM10.1, Ach2

Cell line abbreviations




Deoxyribonucleic acid


Gold sodium thiomalate






Highly active antiretroviral therapy


Hydrogen gold chloride


Human immunodeficiency virus




Interleukin-2 receptor


Nuclear factor kappa B




Peripheral blood mononuclear cells




Ribonucleic acid


Reverse transcriptase




Tumor necrosis factor-alpha




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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Pascaline N. Fonteh
    • 1
  • Frankline K. Keter
    • 1
  • Debra Meyer
    • 1
  1. 1.Department of BiochemistryUniversity of PretoriaPretoriaSouth Africa

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