Advertisement

Biometals

, Volume 19, Issue 1, pp 83–89 | Cite as

Memory Deficit in Mice Administered Aluminum–maltolate Complex

  • Noritsugu Kaneko
  • Jitsuya Takada
  • Hiroyuki Yasui
  • Hiromu Sakurai
Article

Abstract

Recently, aluminum (Al) has been identified as one of the environmental factors responsible for cause certain nerve degeneration diseases, particularly, Alzheimer’s disease (AD). However, the relationship between Al and AD is controversial. We previously examined whether Al induced neurotoxin in the brain of mice when aluminum–maltolate complex (ALM) was administered daily for 120 days. Our results revealed that Al accumulated in the brain induced oxidative stress, and the nerve degeneration was detected in the brain of the ALM-treated group. On the basis of these results, we have tried to examine whether the incorporated Al affects memory in mice with regard to an indicator of spatial memory deficits depending on the chemical forms of Al, namely, as an ion (AlCl3) and in the form of a complex (ALM). We administered saline, AlCl3, and ALM at a concentration of 40 μmol Al/kg body weight to mice by daily ip injections for 60 days. We assessed spatial memory by a water maze task and determined the Al levels in the brain of the mice by the neutron activation analysis method. Spatial memory deficit as an indicator of the swimming time was related to Al accumulation in the brain of mice; the chemical form of the Al compound was important in order to exhibit the memory deficit in mice; the uptake of Al is higher in mice when it is administered in a complex form than in an ionic form.

Keywords

aluminum–maltolate complex spatial memory aluminum accumulation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alfrey, AC, LeGendre, GR, Kaehny, WD 1976The dialysis encephalopathy syndrome. Possible aluminum intoxicationN Engl J Med294184188PubMedGoogle Scholar
  2. Bolla, KI, Briefel, G, Spector, D, Schwartz, BS, Wieler, L, Herron, J, Gimenez, L 1992Neurocognitive effects of aluminumArch Neurol4910211026PubMedGoogle Scholar
  3. Candy, JM, Oakley, AE, Klinowski, J, Carpenter, TA, Perry, RH, Atack, JR, Perry, EK, Blessed, G, Fairbairn, A, Edwardson, JA 1986Aluminosilicates and senile plaque formation in Alzheimer’s diseaseLancet1354357PubMedGoogle Scholar
  4. Clayton, RM, Sedowofia, SK, Rankin, JM, Manning, A 1992Long-term effects of aluminium on the fetal mouse brainLife Sci5119211928CrossRefPubMedGoogle Scholar
  5. Exley, C. eds. 2001Aluminum and Alzheimer’s Disease, The Science that Describes the LinkElsevierAmsterdamGoogle Scholar
  6. FDA. 2001 Federal Register 66:7864–7865.Google Scholar
  7. Finnegan, MM, Lutz, TG, Nelson, WO, Smith, A, Orvig, C 1987Neutral water-soluble post-transition-metal chelate complexes of medical interest: aluminum and gallium tris(3-hydroxy-4-pyronates)Inorg Chem2621712176CrossRefGoogle Scholar
  8. Forbes, WF, Hayward, LM, Agwani, N 1991Dementia, aluminium, and fluorideLancet33815921593CrossRefPubMedGoogle Scholar
  9. Gauthier, E, Fortier, I, Courchesne, F, Pepin, P, Mortimer, J, Gauvreau, D 2000Aluminum forms in drinking water and risk of Alzheimer’s diseaseEnviron Res84234246CrossRefPubMedGoogle Scholar
  10. Good, PF, Olanow, CW, Perl, DP 1992Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson’s disease: a LAMMA studyBrain Res593343346CrossRefPubMedGoogle Scholar
  11. Good, PF, Perl, DP, Bierer, LM, Schmeidler, J 1992Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer’s disease: a laser microprobe (LAMMA) studyAnn Neurol31286292CrossRefPubMedGoogle Scholar
  12. Hino, T, Hatanaka, T, Sano, Y, Oka, S, Tawa, R, Takada, J, Matsusita, R, Sakurai, H 1996Aluminum distribution in organs of animals treated with aluminum ion and its complexBiomed Res Trace Elem72533Google Scholar
  13. Hollosi, M, Shen, ZM, Perczel, A, Fasman, GD 1994Stable intrachain and interchain complexes of neurofilament peptides: a putative link between Al3+ and Alzheimer diseaseProc Natl Acad Sci USA9149024906PubMedGoogle Scholar
  14. JECFA. 1989 The 33rd Meeting of the Joint FAO/WHO Expert Committee on Food AdditivesGoogle Scholar
  15. Johnson, VJ, Kim, SH, Sharma, RP 2005aluminum–maltolate induces apoptosis and necrosis in neuro-2a cells: potential role for p53 signalingToxicol Sci83329339PubMedGoogle Scholar
  16. Kaneko, N, Yasui, H, Takada, J, Suzuki, K, Sakurai, H 2004Orally administrated aluminum–maltolate complex enhances oxidative stress in the organs of miceJ Inorg Biochem9820222031CrossRefPubMedGoogle Scholar
  17. Kawahara, M, Kato, M, Kuroda, Y 2001Effects of aluminum on the neurotoxicity of primary cultured neurons and on the aggregation of beta-amyloid proteinBrain Res Bull55211217CrossRefPubMedGoogle Scholar
  18. Kawahara, M, Kato-Negishi, M, Hosoda, R, Imamura, L, Tsuda, M, Kuroda, Y 2003Brain-derived neurotrophic factor protects cultured rat hippocampal neurons from aluminum–maltolate neurotoxicityJ Inorg Biochem97124131CrossRefPubMedGoogle Scholar
  19. Kawahara, M 1999Trace Elements in the pathogenesis of Alzheimer’s diseaseBiomed Res Trace Eleme10112Google Scholar
  20. Klatzo, I, Wisniewski, H, Streicher, E 1965Experimental production of neurofibrillary degeneration. I. Light microscopic observationsJ Neuropath Exp Neurol24187199PubMedGoogle Scholar
  21. Lipman, JJ, Colowick, SP, Lawrence, PL, Abumrad, NN 1988Aluminum induced encephalopathy in the ratLife Sci42863875CrossRefPubMedGoogle Scholar
  22. Martin, RB 1994Aluminum: a neurotoxic product of acid rainAcc Chem Res27204210CrossRefGoogle Scholar
  23. Martyn, CN, Barker, DJP, Osmond, C, Harris, EC, Edwardson, JA, Lagey, RF 1989Geographical relation between Alzheimer’s disease and aluminum in drinking waterLancet15962PubMedGoogle Scholar
  24. McLachlan, DR, Bergeron, C, Smith, JE, Boomer, D, Rifat, SL 1996Risk for neuropathologically confirmed Alzheimer’s disease and residual aluminum in municipal drinking water employing weighted residential historiesNeurology46401405PubMedGoogle Scholar
  25. Ministry of Health, Labour and Welfare. 2003 Pharmaceuticals and Medical Devices Safety Information No.179 Google Scholar
  26. Miu, AC, Andreescu, CE, Vasiu, R, Olteanu, AI 2003A behavioral and histological study of the effects of long-term exposure of adult rats to aluminumIntern J Neurosci11311971211Google Scholar
  27. Montogomery, EB,Jr 1995Heavy metals and the etiology of Parkinson’s disease and other movement disordersToxicology9739Google Scholar
  28. Neri, LC, Hewitt, D 1991Aluminium, Alzheimer’s disease, and drinking waterLancet338390CrossRefPubMedGoogle Scholar
  29. Pratico, D, Uryu, K, Sung, S, Tang, S, Trojanowski, JQ, Lee, VMY 2002Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic miceFASEB J1611381140PubMedGoogle Scholar
  30. Reinke, CM, Breitkreutz, J, Leuenberger, H 2003Aluminium in over-the-counter drugs: risks outweigh benefitsDrug Safety2610111025CrossRefPubMedGoogle Scholar
  31. Ginkel, MF, Voet, GB, D’Haese, PC, Broe, ME, Wolff, FA 1993Effect of citric acid and maltol on the accumulation of aluminum in rat brain and boneJ Lab Clin Med121453460PubMedGoogle Scholar
  32. WHO. 1997 Environmental Health Criteria, 194Google Scholar
  33. Waggoner, DJ, Bartnikas, TB, Gitlin, JD 1999The role of copper in neurodegenerative diseaseNeurobiol Dis6221230CrossRefPubMedGoogle Scholar
  34. Yasui, M, Yase, Y, Ota, K, Garruto, RM 1991Aluminum deposition in the central nervous system of patients with amyotrophic lateral sclerosis from the Kii Peninsula of JapanNeurotoxicology12615620PubMedGoogle Scholar
  35. Yoshida, H, Yoshimasu, F 1996Alzheimer’s disease and trace elementsNippon Rinsyo54111116Google Scholar

Copyright information

© Springer 2006

Authors and Affiliations

  • Noritsugu Kaneko
    • 1
    • 3
  • Jitsuya Takada
    • 2
  • Hiroyuki Yasui
    • 1
  • Hiromu Sakurai
    • 1
  1. 1.Department of Analytical and Bioinorganic ChemistryKyoto Pharmaceutical UniversityKyotoJapan
  2. 2.Research Reactor InstituteKyoto UniversityOsakaJapan
  3. 3.R&D Headquarters, Alfresa Pharma CorporationOsakaJapan

Personalised recommendations