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Alterations in the lipid content of pituitary gland and serum prolactin and growth hormone in cadmium treated rats

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Abstract

The present study was undertaken to assess whether chronic exposition to cadmium (Cd, 0.133 mM per liter for 2 months) through drinking water may affect the lipid contents in the pituitary anterior lobe (PAL) of adult male Wistar rats. As compared to metal non-exposed controls, PALs exposed to cadmium showed an increase in total phospholipid contents, which was associated to an increase of the incorporation of [1−14C]-methyl choline into phosphatidylcholine and of [U−14C]-glucose into total phospholipids. The incorporation of [1−14C]-methyl choline into sphingomyelin was not changed. Incorporation of [1−14C]-acetate into total fatty acids also increased but incorporation of [1−14C]-acetate into cholesterol did not change. The activity of phospholipase D decreased both in PALs from Cd exposed rats and in PAL dispersed cells treated with Cd in the culture medium from Cd non-exposed rats. In PALS from Cd exposed rats, a decrease of serum prolactin and growth hormone concentrations was determined. The results shown that cadmium modifies the lipid contents of pituitary gland and directly or indirectly the levels of prolactin and growth hormone in serum.

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Authors and Affiliations

  1. Laboratorio de Química Biológica, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Avenida Ejército de los Andes 954, 5700, San Luis

    Ana María Calderoni, Liliana Oliveros & María Sofía Giménez

  2. CRICYT, CONICET, IHEM Universidad Nacional de Cuyo e INBECU, Mendoza

    Graciela Jahn

  3. Laboratorio de Química Analítica y, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, 5700, San Luis, Argentina

    Rosa Anton

  4. Laboratorio de Alimentos, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, 5700, San Luis, Argentina

    Juan Luco

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  1. Ana María Calderoni
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  2. Liliana Oliveros
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  3. Graciela Jahn
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  4. Rosa Anton
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  6. María Sofía Giménez
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Correspondence to Ana María Calderoni.

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Calderoni, A.M., Oliveros, L., Jahn, G. et al. Alterations in the lipid content of pituitary gland and serum prolactin and growth hormone in cadmium treated rats. Biometals 18, 213–220 (2005). https://doi.org/10.1007/s10534-005-0581-4

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  • DOI: https://doi.org/10.1007/s10534-005-0581-4

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