Abstract
Objective
To develop a new and efficient biocatalytic synthesis method of imidazole-4-acetic acid (IAA) from l-histidine (l-His).
Results
l-His was converted to imidazole-4-pyruvic acid (IPA) by an Escherichia coli whole-cell biocatalyst expressing membrane-bound l-amino acid deaminase (ml-AAD) from Proteus vulgaris firstly. The obtained IPA was subsequently decarboxylated to IAA under the action of H2O2. Under optimum conditions, 34.97 mM IAA can be produced from 50 mM l-His, with a yield of 69.9%.
Conclusions
Compared to the traditional chemical synthesis, this biocatalytic method for IAA production is not only environmentally friendly, but also more cost effective, thus being promising for industrial IAA production.
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Change history
21 June 2018
In the original publication of the article, the affiliations of authors Jun Huang, Changjiang Lv and Jiaqi Mei were misplaced. The correct information for author affiliations is provided in this correction.
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Acknowledgements
This work was supported by the Grants from the National Natural Science Foundation of China (31670804, 31470793, 21376217), China Postdoctoral Science Foundation (2016M592003), Zhejiang Provincial Natural Science Foundation (LY16B060008), and the General Scientific Research Project of Zhejiang Provincial Education Department (Y201432760).
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Zhao, W., Ding, H., Hu, S. et al. An efficient biocatalytic synthesis of imidazole-4-acetic acid. Biotechnol Lett 40, 1049–1055 (2018). https://doi.org/10.1007/s10529-018-2569-5
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DOI: https://doi.org/10.1007/s10529-018-2569-5