Biotechnology Letters

, Volume 40, Issue 7, pp 1015–1027 | Cite as

BST2 promotes cell proliferation, migration and induces NF-κB activation in gastric cancer

  • Weiyu Liu
  • Yong Cao
  • Yadi Guan
  • Changqing Zheng
Original Research Paper



To investigate the functional roles of bone marrow stromal cell antigen 2 (BST2) in gastric cancer (GC) cells and its implications in the development of GC patients.


BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demonstrated that knockdown of BST2 by siRNA inhibited cell proliferation, induced apoptosis and repressed cell motility in GC cells. In addition, the pro-tumor function of BST2 in GC was mediated partly through the NF-κB signaling.


BST2 possesses the oncogenic potential in GC by regulating the proliferation, apoptosis, and migratory ability of GC cells, thereby BST2 could be a potential therapeutic target for the treatment of GC.


BST2 Gastric cancer Proliferation Apoptosis NFκB 


Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Weiyu Liu
    • 1
    • 2
  • Yong Cao
    • 1
  • Yadi Guan
    • 1
  • Changqing Zheng
    • 1
  1. 1.Department of GastroenterologyShengjing Hospital of China Medical UniversityShenyangPeople’s Republic of China
  2. 2.Department of GastroenterologyThe People’s Hospital of Liaoning ProvinceShenyangPeople’s Republic of China

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