Preparation of electrospun core–sheath yarn with enhanced bioproperties for biomedical materials
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To create a multifunctional medical material that combines the advantages of both nanofibers and macroyarns.
A novel electrospinning-based approach was developed for creating polycaprolactone (PCL) nanofiber covered yarns (PCL-NCYs) in which polyglycolic acid multi-strand filaments (PGA-MFs) were used as the core. BALB/3T3 (mouse embryonic fibroblast cell line) cells were cultured on the PCL-NCYs substrate and cell morphology and proliferation were determined by methylthiazol tetrazolium (MTT) assay. Compared with PGA-MFs, PCL-NCYs had a higher porosity and tensile strength of 88 ± 8% and 348 ± 16 MPa and in particular, the porosity was four times higher. BALB/3T3 cells attached more easily onto the nanofiber structure and proliferated along the direction of nanofibers, indicating that PCL-NCYs can achieve better cell differentiation and proliferation.
PCL-NCYs can be created by combining electrospinning covering and textile twisting, and have better mechanical property and higher porosity, and can be used as a novel scaffold in tissue engineering.
KeywordsBiomedical materials Core–sheath structure Electrospinning Nanofibers Mechanical property Porosity Tissue scaffolds
This work was supported by grants from National Natural Science Foundation of China (51503168), Shaanxi Innovation Talent Promotion Program-Project for Youth New Star of Science and Technology (2017KJXX-23), Special Funding for Postdoctoral Innovation Project in Shandong Province (201504), Disciplinary Construction Fund for Textile Science and Engineering of Xi’an Polytechnic University (10709-0821), and Xi’an Polytechnic University Innovation Fund for Graduate Students (CX201729).