Biotechnology Letters

, Volume 40, Issue 2, pp 279–284 | Cite as

Preparation of electrospun core–sheath yarn with enhanced bioproperties for biomedical materials

  • Boyu Li
  • Chengkun Liu
  • Fenglei Zhou
  • Xue Mao
  • Runjun Sun
Original Research Paper
  • 84 Downloads

Abstract

Objectives

To create a multifunctional medical material that combines the advantages of both nanofibers and macroyarns.

Results

A novel electrospinning-based approach was developed for creating polycaprolactone (PCL) nanofiber covered yarns (PCL-NCYs) in which polyglycolic acid multi-strand filaments (PGA-MFs) were used as the core. BALB/3T3 (mouse embryonic fibroblast cell line) cells were cultured on the PCL-NCYs substrate and cell morphology and proliferation were determined by methylthiazol tetrazolium (MTT) assay. Compared with PGA-MFs, PCL-NCYs had a higher porosity and tensile strength of 88 ± 8% and 348 ± 16 MPa and in particular, the porosity was four times higher. BALB/3T3 cells attached more easily onto the nanofiber structure and proliferated along the direction of nanofibers, indicating that PCL-NCYs can achieve better cell differentiation and proliferation.

Conclusions

PCL-NCYs can be created by combining electrospinning covering and textile twisting, and have better mechanical property and higher porosity, and can be used as a novel scaffold in tissue engineering.

Keywords

Biomedical materials Core–sheath structure Electrospinning Nanofibers Mechanical property Porosity Tissue scaffolds 

Notes

Acknowledgements

This work was supported by grants from National Natural Science Foundation of China (51503168), Shaanxi Innovation Talent Promotion Program-Project for Youth New Star of Science and Technology (2017KJXX-23), Special Funding for Postdoctoral Innovation Project in Shandong Province (201504), Disciplinary Construction Fund for Textile Science and Engineering of Xi’an Polytechnic University (10709-0821), and Xi’an Polytechnic University Innovation Fund for Graduate Students (CX201729).

References

  1. Horst M, Madduri S, Milleret V, Sulser T, Gobet R (2013) A bilayered hybrid microfibrous PLGA-acellular matrix scaffold for hollow organ tissue engineering. Biomaterials 34:1537–1545CrossRefPubMedGoogle Scholar
  2. Jayasinghe SN (2013) Cell electrospinning: a novel tool for functionalising fibres, scaffolds and membranes with living cells and other advanced materials for regenerative biology and medicine. Analyst 138:2215–2223CrossRefPubMedGoogle Scholar
  3. Jiang T, Carbone EJ, Lo WH, Laurencin CT (2015) Electrospinning of polymer nanofibers for tissue regeneration. Prog Polym Sci 46:1–24CrossRefGoogle Scholar
  4. Joseph J, Nair SV, Menon D (2015) Integrating substrateless electrospinning with textile technology for creating biodegradable three-dimensional structures. Nano Lett 15:5420–5426CrossRefPubMedGoogle Scholar
  5. Li WJ, Laurencin CT, Caterson EJ, Tuan RS, Ko FK (2002) Electrospun nanofibrous structure: a novel scaffold for tissue engineering. J Biomed Mater Res A 60:613–621CrossRefGoogle Scholar
  6. Li D, Pan X, Sun B, Wu T, Chen W, Huang C, Ke Q, EI-Hamshary HA, Al-Deyabd SS, Mo X (2015) Nerve conduits constructed by electrospun P(LLA-CL) nanofibers and PLLA nanofiber yarns. J Mater Chem B 3:8823–8831CrossRefGoogle Scholar
  7. Mandal BB, Kundu SC (2009) Cell proliferation and migration in silk fibroin 3D scaffolds. Biomaterials 30:2956–2965CrossRefPubMedGoogle Scholar
  8. Mouthuy PA, Zargar N, Hakimi O, Lostis E, Carr A (2015) Fabrication of continuous electrospun filaments with potential for use as medical fibres. Biofabrication 7:025006CrossRefPubMedGoogle Scholar
  9. Padmakumar S, Joseph J, Neppalli MH, Mathew SE, Nair SV, Shankarappa SA, Menon D (2016) Electrospun polymeric core–sheath yarns as drug eluting surgical sutures. ACS Appl Mater Interface 8:6925–6934CrossRefGoogle Scholar
  10. Sill TJ, von Recum HA (2008) Electrospinning: applications in drug delivery and tissue engineering. Biomaterials 29:1989–2006CrossRefPubMedGoogle Scholar
  11. Subbiah T, Bhat GS, Tock RW, Parameswaran S, Ramkumar SS (2005) Electrospinning of nanofibers. J Appl Polym Sci 96:557–569CrossRefGoogle Scholar
  12. Tan L, Hu J, Huang H, Han J, Hu H (2015) Study of multi-functional electrospun composite nanofibrous mats for smart wound healing. Int J Biol Macromol 79:469–476CrossRefPubMedGoogle Scholar
  13. Townsend-Nicholson A, Jayasinghe SN (2006) Cell electrospinning: a unique biotechnique for encapsulating living organisms for generating active biological microthreads/scaffolds. Biomacromolecules 7:3364–3369CrossRefPubMedGoogle Scholar
  14. Wu J, Liu S, He L, Wang H, He C, Fan C, Mo X (2012) Electrospun nanoyarn scaffold and its application in tissue engineering. Mater Lett 89:146–149CrossRefGoogle Scholar
  15. Wu J, Huang C, Liu W, Yin A, Chen W, He C, Wang H, Liu S, Fan C, Bowlin GL, Mo X (2014) Cell infiltration and vascularization in porous nanoyarn scaffolds prepared by dynamic liquid electrospinning. J Biomed Nanotechnol 10:603–614CrossRefPubMedGoogle Scholar
  16. Wu S, Duan B, Qin X, Butcher JT (2017) Living nano-micro fibrous woven fabric/hydrogel composite scaffolds for heart valve engineering. Acta Biomater 51:89–100CrossRefPubMedGoogle Scholar
  17. Xue J, Niu Y, Gong M, Shi R, Chen D, Zhang L, Lvov Y (2015) Electrospun microfiber membranes embedded with drug-loaded clay nanotubes for sustained antimicrobial protection. ACS Nano 9:1600–1612CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2017

Authors and Affiliations

  • Boyu Li
    • 1
  • Chengkun Liu
    • 1
    • 2
  • Fenglei Zhou
    • 3
  • Xue Mao
    • 1
  • Runjun Sun
    • 1
  1. 1.School of Textile and MaterialsXi’an Polytechnic UniversityXi’anChina
  2. 2.College of TextilesDonghua UniversityShanghaiChina
  3. 3.Division of Informatics, Imaging and Data SciencesThe University of ManchesterManchesterUK

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