Abstract
A genetic component is accepted in the etiology of the glioma. Evidence from candidate genes studies and GWAS reveal that CCDC26 gene could increase the risk of glioma. We performed a systematic review and up-to-date meta-analysis to explore if polymorphisms of CCDC26 gene (rs891835, rs6470745, and rs55705857) may be a susceptibility factor in developing glioma. An online search in PubMed, Web of Science, and SCOPUS up to September 2018 was performed. The pooled odds ratios were evaluated by fixed effects model and random effects model. Analyses of the overall sample and ethnic sub-groups were performed. In all the analyses, the allelic, additive, dominant, and recessive models were used. We found an association between all polymorphisms evaluated and an increased risk for glioma in the overall population in all the models studied. In sub-group analysis, we found that rs891835 and rs6470745 increased the risk of glioma in Europeans and Caucasians. On the other hand, the rs891835 polymorphism did not reveal any statistical association in Chinese population. Taken into consideration the limitations of this study, the present findings suggest a possible participation of rs891835, rs6470745, and rs55705857 as risk factors to develop glioma. Furthermore, it is possible that the involvement of CCDC26 variants depends on ethnicity. However, we recommend to perform further studies to have conclusive outcomes.
Similar content being viewed by others
References
Adel Fahmideh M et al (2015) CCDC26, CDKN2BAS, RTEL1 and TERT polymorphisms in pediatric brain tumor susceptibility. Carcinogenesis 36:876–882. https://doi.org/10.1093/carcin/bgv074
Barnholtz-Sloan JS, Maldonado JL, Williams VL, Curry WT, Rodkey EA, Barker FG 2nd, Sloan AE (2007) Racial/ethnic differences in survival among elderly patients with a primary glioblastoma. J Neurooncol 85:171–180. https://doi.org/10.1007/s11060-007-9405-4
Chen H et al (2011) Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population. Am J Epidemiol 173:915–922. https://doi.org/10.1093/aje/kwq457
Cui T (2015) CCDC26 rs4295627 polymorphism and glioma risk: a meta-analysis. Int J Clin Exp Med 8:3862–3868
Di Stefano AL et al (2013) Association between glioma susceptibility loci and tumour pathology defines specific molecular etiologies. Neuro Oncol 15:542–547. https://doi.org/10.1093/neuonc/nos284
Egan KM et al (2011) Cancer susceptibility variants and the risk of adult glioma in a US case–control study. J Neurooncol 104:535–542. https://doi.org/10.1007/s11060-010-0506-0
Egan KM, Wrensch MR, Jenkins RB (2012) Rare and uncommon genetic variants may hold key to the ‘missing heritability’ in glioma CNS. Oncol 1:109–112. https://doi.org/10.2217/cns.12.19
Enciso-Mora V et al (2013) Deciphering the 8q24.21 association for glioma. Hum Mol Genet 22:2293–2302. https://doi.org/10.1093/hmg/ddt063
Ghasimi S, Wibom C, Dahlin AM, Brannstrom T, Golovleva I, Andersson U, Melin B (2016) Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma. J Neurooncol 127:483–492. https://doi.org/10.1007/s11060-016-2066-4
Gonzalez-Castro TB, Hernandez-Diaz Y, Juarez-Rojop IE, Lopez-Narvaez ML, Tovilla-Zarate CA, Genis-Mendoza A, Alpuin-Reyes M (2016) The role of C957T, TaqI and Ser311Cys polymorphisms of the DRD2 gene in schizophrenia: systematic review and meta-analysis. Behav Brain Funct (BBF) 12:29. https://doi.org/10.1186/s12993-016-0114-z
Hernandez-Diaz Y et al (2016) Effects of paraoxonase 1 gene polymorphisms on heart diseases: systematic review and meta-analysis of 64 case–control studies. Medicine (Baltimore) 95:e5298. https://doi.org/10.1097/md.0000000000005298
Jenkins RB et al (2011) Distinct germ line polymorphisms underlie glioma morphologic heterogeneity. Cancer Genet 204:13–18. https://doi.org/10.1016/j.cancergencyto.2010.10.002
Jenkins RB et al (2012) A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation. Nat Genet 44:1122–1125. https://doi.org/10.1038/ng.2388
Kinnersley B, Houlston RS, Bondy ML (2018) Genome-wide association studies in glioma. Cancer Epidemiol Biomarkers Prev 27:418–428. https://doi.org/10.1158/1055-9965.epi-17-1080
Lachance DH et al (2011) Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking. Am J Epidemiol 174:574–581. https://doi.org/10.1093/aje/kwr124
Lasho TL et al (2012) Differential distribution of CCDC26 glioma-risk alleles in myeloid malignancies with mutant IDH1 compared with their IDH2R140-mutated or IDH-unmutated counterparts. Leukemia 26:1406–1407. https://doi.org/10.1038/leu.2011.336
Li S et al (2012) Polymorphisms of TREH, IL4R and CCDC26 genes associated with risk of glioma. Cancer Epidemiol 36:283–287. https://doi.org/10.1016/j.canep.2011.12.011
Li M, Zhou Q, Tu C, Jiang Y (2013) A meta-analysis of an association between the XRCC1 polymorphisms and gliomas risk. J Neurooncol 111:221–228. https://doi.org/10.1007/s11060-012-1022-1
Liu Y et al (2010a) Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival. J Clin Oncol 28:2467–2474. https://doi.org/10.1200/jco.2009.26.6213
Liu Y, Shete S, Hosking F, Robertson L, Houlston R, Bondy M (2010b) Genetic advances in glioma: susceptibility genes and networks. Curr Opin Genet Dev 20:239–244. https://doi.org/10.1016/j.gde.2010.02.001
Liu Y, Shete S, Hosking FJ, Robertson LB, Bondy ML, Houlston RS (2010c) New insights into susceptibility to glioma. Arch Neurol 67:275–278. https://doi.org/10.1001/archneurol.2010.4
Lu HW, Huang M, Wang JH, Sun XL, Ke YQ (2015) CCDC26 rs4295627 polymorphism (8q24.21) and glioma risk: a meta-analysis. Genet Mol Res 14:12074–12084. https://doi.org/10.4238/2015.october.5.20
Melin B (2011) Genetic causes of glioma: new leads in the labyrinth. Curr Opin Oncol 23:643–647. https://doi.org/10.1097/CCO.0b013e32834a6f61
Melin BS et al (2017) Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. Nat Genet 49:789–794. https://doi.org/10.1038/ng.3823
Oktay Y et al (2016) IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation. Sci Rep 6:27569. https://doi.org/10.1038/srep27569
Ostrom QT et al (2018) Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21. Sci Rep 8:7352. https://doi.org/10.1038/s41598-018-24580-z
Pop S, Enciu AM, Necula LG, Tanase C (2018) Long non-coding RNAs in brain tumours: focus on recent epigenetic findings in glioma. J Cell Mol Med. https://doi.org/10.1111/jcmm.13781
Rajaraman P et al (2012) Genome-wide association study of glioma and meta-analysis. Hum Genet 131:1877–1888. https://doi.org/10.1007/s00439-012-1212-0
Richardson TE et al (2017) Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis. J Neurooncol 133:183–192. https://doi.org/10.1007/s11060-017-2431-y
Schoemaker MJ et al (2010) Interaction between 5 genetic variants and allergy in glioma risk. Am J Epidemiol 171:1165–1173. https://doi.org/10.1093/aje/kwq075
Shabihkhani M et al (2017) Incidence, survival, pathology, and genetics of adult Latino Americans with glioblastoma. J Neurooncol 132:351–358. https://doi.org/10.1007/s11060-017-2377-0
Shete S et al (2009) Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet 41:899–904. https://doi.org/10.1038/ng.407
Simon M et al (2010) Genetic risk profiles identify different molecular etiologies for glioma. Clin Cancer Res 16:5252–5259. https://doi.org/10.1158/1078-0432.ccr-10-1502
Vaubel RA et al (2017) Synchronous gemistocytic astrocytoma IDH-mutant and oligodendroglioma IDH-mutant and 1p/19q-codeleted in a patient with CCDC26 polymorphism. Acta Neuropathol 134:317–319. https://doi.org/10.1007/s00401-017-1727-5
Walsh KM et al (2013a) Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies. Genet Epidemiol 37:222–228. https://doi.org/10.1002/gepi.21707
Walsh KM et al (2013b) Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis. Neuro Oncol 15:1041–1047. https://doi.org/10.1093/neuonc/not051
Wang SS et al (2011) Joint associations between genetic variants and reproductive factors in glioma risk among women. Am J Epidemiol 174:901–908. https://doi.org/10.1093/aje/kwr184
Wang X, Luo T, Ruan M, Liu P, Wang S, Zhu W (2016) Association of the CCDC26 rs4295627 polymorphism with the risk of glioma: evidence from 7,290 cases and 11,630 controls. Mol Clin Oncol 4:878–882. https://doi.org/10.3892/mco.2016.813
Wang S, Hui Y, Li X, Jia Q (2018) Silencing of lncRNA CCDC26 restrains the growth and migration of glioma cells in vitro and in vivo via targeting miR-203. Oncol Res 26:1143–1154. https://doi.org/10.3727/096504017x14965095236521
Wei XB et al (2014) CCDC26 gene polymorphism and glioblastoma risk in the Han Chinese population. Asian Pac J Cancer Prev 15:3629–3633
Wibom C et al (2015) Investigation of established genetic risk variants for glioma in prediagnostic samples from a population-based nested case–control study. Cancer Epidemiol Biomarkers Prev 24:810–816. https://doi.org/10.1158/1055-9965.epi-14-1106
Wu Q, Peng Y, Zhao X (2016) An updated and comprehensive meta-analysis of association between seven hot loci polymorphisms from eight GWAS and glioma risk. Mol Neurobiol 53:4397–4405. https://doi.org/10.1007/s12035-015-9346-4
Zeng J, Luo Y, Yu M, Li J, Liu Z (2017) CCDC26 rs4295627 polymorphisms associated with an increased risk of glioma: a meta-analysis. Adv Clin Exp Med 26:1275–1281
Funding
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Author information
Authors and Affiliations
Contributions
T.B.G.C., C.A.T.Z., and A.D.G.M. performed substantial contributions to conception and design; J.J.M.M., T.B.G.C., and J.M.R.P. participated in acquisition of data, or analysis and interpretation of data; I.E.J.R., M.L.L.N., and N.P.H. drafted the article or revised it critically for important intellectual content; and all the authors gave their final approval of the version to be published.
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
González-Castro, T.B., Juárez-Rojop, I.E., López-Narváez, M.L. et al. Genetic Polymorphisms of CCDC26 rs891835, rs6470745, and rs55705857 in Glioma Risk: A Systematic Review and Meta-analysis. Biochem Genet 57, 583–605 (2019). https://doi.org/10.1007/s10528-019-09911-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10528-019-09911-7