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MIR146A rs2910164 (G/C) Polymorphism is Associated with Incidence of Preeclampsia in Gestational Diabetes Patients

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Abstract

Preeclampsia and gestational diabetes are common pregnancy disorders that may be interrelated. MIR146A rs2910164 (G/C) is a functional polymorphism that was associated with several diseases. This study aimed to investigate the frequency of rs2910164 polymorphism and its possible correlation with the incidence of preeclampsia in gestational diabetes patients. The study involved 250 pregnant women divided into 80 healthy control subjects, 85 gestational diabetes patients only, and 85 patients of gestational diabetes combined with preeclampsia. Systolic and diastolic blood pressures, urinary proteins, kidney and liver functions, glucose homeostasis parameters, and lipid profile were determined. Genotyping of the polymorphism was conducted by PCR-RFLP. The frequency of the minor C allele of rs2910164 polymorphism was significantly higher among patients of gestational diabetes combined with preeclampsia compared to the control group (p = 0.012) and the gestational diabetes group (p = 0.014). Patients of gestational diabetes and preeclampsia carrying CC genotype showed higher systolic and diastolic blood pressure, and increased urea, creatinine, urine protein, and dyslipidemia compared to the carriers of GG and GC genotypes. In conclusion, the results of the current study suggest that the rare CC genotype of MIR146A rs2910164 (G/C) polymorphism may be related to increased incidence of preeclampsia in gestational diabetes patients.

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Acknowledgements

The authors are thankful to the staff members of the Obstetrics and Gynecology Department in the Suez Canal University Hospital and tha Ismailia General Hospital for their help in the collection of samples.

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The work was funded by the authors.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt

    Dina M. Abo-Elmatty & Eman T. Mehanna

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  1. Dina M. Abo-Elmatty
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  2. Eman T. Mehanna
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Correspondence to Eman T. Mehanna.

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All the participants in the study provided written informed consent following a protocol approved by the Research Ethics Committee of Faculty of Pharmacy, Suez Canal University (Code: 201709RH1). The study followed the principles of the Declaration of Helsinki.

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Abo-Elmatty, D.M., Mehanna, E.T. MIR146A rs2910164 (G/C) Polymorphism is Associated with Incidence of Preeclampsia in Gestational Diabetes Patients. Biochem Genet 57, 222–233 (2019). https://doi.org/10.1007/s10528-018-9886-1

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