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Genetic Association of rs1800780 (A→G) Polymorphism of the eNOS Gene with Susceptibility to Essential Hypertension in a Chinese Han Population

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Abstract

To investigate the association of eNOS gene polymorphism with essential hypertension in the Chinese Han population, we examined polymorphisms of the rs2070744 (T→C), rs1800780 (A→G), and rs3918181 (A→G) loci. The results demonstrated that the genotypic frequency at the rs1800780 (A→G) locus was significantly different between patients with essential hypertension and the control cohorts (P < 0.05); while genotypic frequencies and allelic frequencies at rs2070744 (T→C) and rs3918181 (A→G) loci had no statistical difference between the patient group and controls (P > 0.05). In addition, haplotype analysis found a statistically significant difference for haplotype TGA, with OR (95% CI) of 1.549 (1.116–2.150) (P < 0.05). These findings suggest that polymorphism of rs1800780 (A→G) in the eNOS gene may be one of the most important genetic factors associated with essential hypertension susceptibility, and those who have haplotype TGA may be at risk to develop essential hypertension.

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Acknowledgments

This study was supported by grants from Natural Science Foundation of Ningxia Hui Autonomous Region of China (Grant No. NZ1042) and the Foundation for Scientific Research of Ningxia University (Grant No. ZR1126).

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Authors and Affiliations

  1. Key Laboratory of the Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China, Yinchuan, China

    Bo Yang, Xiaoming Liu, Min Li, Yi Yang, Xiaofei Na & Yujiong Wang

  2. College of Life Science, Ningxia University, 539 W. Helanshan Road, Yinchuan, 750021, Ningxia, China

    Bo Yang, Xiaoming Liu, Min Li, Yi Yang, Xiaofei Na & Yujiong Wang

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  1. Bo Yang
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  2. Xiaoming Liu
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  3. Min Li
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  6. Yujiong Wang
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Correspondence to Yujiong Wang.

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Yang, B., Liu, X., Li, M. et al. Genetic Association of rs1800780 (A→G) Polymorphism of the eNOS Gene with Susceptibility to Essential Hypertension in a Chinese Han Population. Biochem Genet 52, 71–78 (2014). https://doi.org/10.1007/s10528-013-9628-3

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  • DOI: https://doi.org/10.1007/s10528-013-9628-3

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