Genetic and Environmental Influences on Language Ability in Older Adults: Findings from the Older Australian Twins Study
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We used a sub-sample from the Older Australian Twins Study to estimate the heritability of performance on three tests of language ability: Boston Naming Test (BNT), Letter/Phonemic Fluency (FAS) and Category/Semantic Fluency (CFT) Tests. After adjusting for age, sex, education, mood, and global cognition (GC), heritability estimates obtained for the three tests were 0.35, 0.59, and 0.20, respectively. Multivariate analyses showed that the genetic correlation were high for BNT and CFT (0.61), but low for BNT and FAS (0.17), and for FAS and CFT (0.28). Genetic modelling with Cholesky decomposition indicated that the covariation between the three measures could be explained by a common genetic factor. Environmental correlations between the language ability measures were low, and there were considerable specific environmental influences for each measure. Future longitudinal studies with language performance and neuroimaging data can further our understanding of genetic and environmental factors involved in the process of cognitive aging.
KeywordsGenetic Heritability Twins Aging Language ability
This research was facilitated through the Australian Twin Registry, a national research resource in part supported by a Centre of Research Excellence Grant from the NHMRC (ID No. 1079102). We thank the participants for their generous contributions to this study. We also thank and acknowledge the editorial assistance of Dr Sophia Dean in the preparation of this manuscript.
The Older Australian Twins Study was supported by the National Health and Medical Research Council (NHMRC, ID No. 401162).
Compliance with ethical standards
Conflict of interest
T. Lee, A. Thalamuthu, J. D. Henry, J. N. Trollor, D. Ames, M. J. Wright, P. S. Sachdev and OATS Research Team declare that they have no conflict of interest.
All procedures/assessments performed in this study involving human participants were in accordance with, and approved by the Human Research Ethics Committee (HC No. 12599) of the University of New South Wales, Australia.
Human and animal rights
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5).
Informed consent was obtained from all individual participants included in the Older Australian Twins Study.
- Abrahams S, Goldstein LH, Simmons A, Brammer MJ, Williams SC, Giampietro VP, Andrew CM, Leigh PN (2003) Functional magnetic resonance imaging of verbal fluency and confrontation naming using compressed image acquisition to permit overt responses. Hum Brain Mapp 20(1):29–40. https://doi.org/10.1002/hbm.10126 PubMedCrossRefGoogle Scholar
- Benton AL, Hamsher KS (1976) Multilingual aphasia examination: manual of instruction. University of Iowa, Iowa CityGoogle Scholar
- Boker S, Neale M, Maes H, Wilde M, Spiegel M, Brick T, Spies J, Estarbook R, Kenny S, Bates T, Mehta P, Fox J (2011) OpenMx: an open source extended structural equation modeling framework. Psychometrika 76(2):306–317. https://doi.org/10.1007/s11336-010-9200-6 PubMedPubMedCentralCrossRefGoogle Scholar
- Brouillette RM, Martin CK, Correa JB, Davis AB, Han H, Johnson WD, Foil HC, Hymel A, Keller JN (2011) Memory for names test provides a useful confrontational naming task for aging and continuum of dementia. J Alzheimers Dis 23(4):665–671. https://doi.org/10.3233/JAD-2011-101455 PubMedPubMedCentralGoogle Scholar
- de Azeredo Passos VM, Giatti L, Bensenor I, Tiemeier H, Ikram MA, de Figueiredo RC, Chor D, Schmidt MI, Barreto SM (2015) Education plays a greater role than age in cognitive test performance among participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). BMC Neurol 15(1):191PubMedPubMedCentralCrossRefGoogle Scholar
- Donovan NJ, Okereke OI, Vannini P, Amariglio RE, Rentz DM, Marshall GA, Johnson KA, Sperling RA (2016) Association of higher cortical amyloid burden with loneliness in cognitively normal older adults. JAMA Psychiatry 73(12):1230–1237. https://doi.org/10.1001/jamapsychiatry.2016.2657 PubMedPubMedCentralCrossRefGoogle Scholar
- Fornito A, Zalesky A, Bassett DS, Meunier D, Ellison-Wright I, Yücel M, Wood SJ, Shaw K, O’Connor J, Nertney D, Mowry BJ, Pantelis C, Bullmore ET (2011) Genetic influences on cost-efficient organization of human cortical functional networks. J Neurosci 31(9):3261–3270. https://doi.org/10.1523/JNEUROSCI.4858-10.2011 PubMedCrossRefGoogle Scholar
- Glisky EL (2007) Changes in cognitive function in human aging. In: Riddle DR (ed) Brain aging: models, methods, and mechanisms. CRC Press, Boca Raton, pp 3–20Google Scholar
- Goodglass H, Kaplan E (1987) Boston diagnostic aphasia examination (BDAE), 2nd edn. Lea & Febiger, PhiladelphiaGoogle Scholar
- Henry JD, Crawford JR, Phillips LH (2004) Verbal fluency performance in dementia of the Alzheimer’s type: a meta-analysis. Neuropsychologia 42(9):1212–1222. https://doi.org/10.1016/j.neuropsychologia.2004.02.001 PubMedCrossRefGoogle Scholar
- Kaplan E, Goodglass H, Weintraub S (2001) Boston naming test, 2nd edn. Lea & Febiger, PhiladelphiaGoogle Scholar
- Lee T, Mosing MA, Henry JD, Trollor JN, Lammel A, Ames D, Martin NG, Wright MJ, Sachdev PS (2012a) Genetic influences on five measures of processing speed and their covariation with general cognitive ability in the elderly: the older Australian twins study. Behav Genet 42(1):96–106. https://doi.org/10.1007/s10519-011-9474-1 PubMedCrossRefGoogle Scholar
- Lee T, Mosing MA, Henry JD, Trollor JN, Ames D, Martin NG, Wright MJ, Sachdev PS, OATS Research Team (2012b) Genetic influences on four measures of executive functions and their covariation with general cognitive ability: the Older Australian Twins Study. Behav Genet 42(4):528–538. https://doi.org/10.1007/s10519-012-9526-1 PubMedCrossRefGoogle Scholar
- Lee T, Lipnicki DM, Crawford JD, Henry JD, Trollor JN, Ames D, Wright MJ, Sachdev PS, OATS Research Team (2014) Leisure activity, health, and medical correlates of neurocognitive performance among monozygotic twins: The Older Australian Twins Study. J Gerontol B 69(4):514–522. https://doi.org/10.1093/geronb/gbt031 CrossRefGoogle Scholar
- Leyton CE, Villemagne VL, Savage S, Pike KE, Ballard KJ, Piguet O, Burrell JR, Rowe CC, Hodges JR (2011) Subtypes of progressive aphasia: application of the international consensus criteria and validation using β-amyloid imaging. Brain 134(Pt 10):3030–3043. https://doi.org/10.1093/brain/awr216 PubMedCrossRefGoogle Scholar
- Lezak MD, Howieson DB, Bigler E, Tranel D (2012) Neuropsychological assessment (fifth edition). Oxford University Press Inc., OxfordGoogle Scholar
- Nelson HE, Willison JR (1991) National adult reading test (NART) test manual, 2nd edn. NFER-Nelson, WindsorGoogle Scholar
- Purcell S (2002) Variance components models for gene–environment interaction in twin analysis. Twin Res 5:554–571Google Scholar
- Roca M, Manes F, Chade A, Gleichgerrcht E, Gershanik O, Arévalo GG, Torralva T, Duncan J (2012) The relationship between executive functions and fluid intelligence in Parkinson’s disease. Psychol Med 42(11):2445–2452. https://doi.org/10.1017/s0033291712000451 PubMedPubMedCentralCrossRefGoogle Scholar
- Sachdev PS, Lammel A, Trollor JN, Lee T, Wright MJ, Ames D, Wen W, Martin NG, Brodaty H, Schofield PR, OATS Research Team (2009) A comprehensive neuropsychiatric study of eldeerly twins: the Older Australian Twins Study. Twin Res Hum Genet 12(6):573–582. https://doi.org/10.1375/twin.12.6.573 PubMedCrossRefGoogle Scholar
- Zhang H, Sachdev PS, Wen W, Kochan NA, Crawford JD, Brodaty H, Slavin MJ, Reppermund S, Kang K, Trollor JN (2013) Grey matter correlates of three language tests in non-demented older adults. PLoS ONE 8(11):e80215. https://doi.org/10.1371/journal.pone.0080215 PubMedPubMedCentralCrossRefGoogle Scholar