Features of Remodeling of Prostate Stroma in Chronic Abacterial Prostatitis

We performed a complex morphological study of biopsy samples of prostate gland from 30 men (mean age 46±11 years) with chronic abacterial prostatitis who were exposed unfavorable anthropogenic factors. The ultrastructural heterogeneity of smooth muscle cells was shown, among which cells with destructive changes in organelles predominated, solitary cells with signs of secretory function were revealed. Most endothelial cells in microvessels were characterized by low pinocytotic activity, destruction of organelles; focal hyperplastic ultrastructural changes were noted in some endotheliocytes. Along with fibroblasts, the stroma contained single mast cells; no inflammatory infiltration was revealed. The results of the study attested to complex mechanisms of remodeling of the prostate gland stroma in chronic abacterial prostatitis involving microvessels, smooth muscle cells, and probably mast cells, which determines the development of degenerative, destructive, and fibrotic processes.

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  1. 1.

    Budnik AF, Urusbambetov ACh, Bogatyreva OE. Morphology of man prostate stroma in postnatal ontogenesis. Morfol. Ved. 2011;(4):19-22. Russian.

    Google Scholar 

  2. 2.

    Kogan MI, Matsionis AE, Belousov II, Povilaitite PE. Morphological evidence of the ischemic nature of the prostatic fibrosis in the classical chronic pelvic pain syndrome / IIIB chronic prostatitis. Urologiya. 2018;(3):12-19. Russian.

    Article  Google Scholar 

  3. 3.

    Neimark AI, Kiptilov AV, Lapii GA. Clinical and pathomorphological features of chronic prostatitis in chemical industry workers. Urologiya. 2015;(6):68-73. Russian.

    Google Scholar 

  4. 4.

    Sedova AO. Effect of chemical and finely-divided air pollutants on spermatogenesis and sperm parameters. Andrologiya Genital. Khirurgiya. 2019;20(2):29-34. Russian.

    Article  Google Scholar 

  5. 5.

    Sivkov AV, Romikh VV, Zakharchenko AV. Chronic prostatitis IIIB/chronic pelvic pain syndrome and sexual dysfunction. Andrologiya Genital. Khirurgiya. 2015;16(4):18-26. Russian.

    Google Scholar 

  6. 6.

    Bianchi-Frias D, Vakar-Lopez F, Coleman IM, Plymate SR, Reed MJ, Nelson PS. The Effects of Aging on the Molecular and Cellular Composition of the Prostate Microenvironment. PLoS One. 2010;5(9):e12501. doi: https://doi.org/10.1371/journal.pone.0012501

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. 7.

    Breser ML, Salazar FC, Rivero VE, Motrich RD. Immunological Mechanisms Underlying Chronic Pelvic Pain and Prostate Inflammation in Chronic Pelvic Pain Syndrome. Front. Immunol. 2017;8:898. doi: https://doi.org/10.3389/fimmu.2017.00898

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  8. 8.

    Conti P, Caraffa A, Mastrangelo F, Tettamanti L, Ronconi G, Frydas I, Kritas SK, Theoharides TC. Critical Role of Inflammatory Mast Cell in Fibrosis: Potential Therapeutic Effect of IL-37. Cell Prolif. 2018;51(5):e12475. doi: https://doi.org/10.1111/cpr.12475

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  9. 9.

    Dellabella M, Milanese G, Sigala S, d’Anzeo G, Arrighi N, Bodei S, Muzzonigro G. The role of the prostatic stroma in chronic prostatitis/chronic pelvic pain syndrome. Inflamm. Res. 2009;58(12):829-836. doi: https://doi.org/10.1007/s00011-009-0086-7

    CAS  Article  PubMed  Google Scholar 

  10. 10.

    Pirola GM, Verdacchi T, Rosadi S, Annino F, De Angelis M. Chronic prostatitis: current treatment options. Res. Rep. Urol. 2019;11:165-174. doi: https://doi.org/10.2147/RRU.S194679

  11. 11.

    Polackwich AS, Shoskes DA. Chronic prostatitis/chronic pelvic pain syndrome: a review of evaluation and therapy. Prostate Cancer Prostatic Dis. 2016;19(2):132-138. doi: https://doi.org/10.1038/pcan.2016.8

    CAS  Article  PubMed  Google Scholar 

  12. 12.

    Schuppe HC, Köhn FM. Impact of lifestyle and environmental factors on male reproductive health. Hautarzt. 2018;69(12):996-1005. doi: https://doi.org/10.1007/s00105-018-4307-2

    Article  PubMed  Google Scholar 

  13. 13.

    Wang GC, Huang TR, Hu YY, Wang KY, Shi H, Yin L, Peng B. Corpus Cavernosum Smooth Muscle Cell Dysfunction and Phenotype Transformation Are Related to Erectile Dysfunction in Prostatitis Rats With Chronic prostatitis/chronic Pelvic Pain Syndrome. J. Inflamm. (Lond). 2020;17:2. doi: https://doi.org/10.1186/s12950-019-0233-z

    CAS  Article  PubMed Central  Google Scholar 

  14. 14.

    Zeng H, He Y, Yu Y, Zhang J, Zeng X, Gong F, Liu Q, Yang B. Resveratrol Improves Prostate Fibrosis During Progression of Urinary Dysfunction in Chronic Prostatitis by Mast Cell Suppression. Mol. Med. Rep. 2018;17(1):918-924. doi: https://doi.org/10.3892/mmr.2017.7960

    CAS  Article  PubMed  Google Scholar 

  15. 15.

    Zhao F, Ye MY, Zhao JF, Lü BD. Henotypic Modulation of Corporal Cavernosum Smooth Muscle Cells and Erectile Dysfunction: Advances in Studies. Zhonghua Nan Ke Xue. 2018;24(10):927-932.

    PubMed  Google Scholar 

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Correspondence to G. A. Lapii.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 9, pp. 388-394, September, 2020

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Lapii, G.A., Molodykh, O.P., Abdullaev, N.A. et al. Features of Remodeling of Prostate Stroma in Chronic Abacterial Prostatitis. Bull Exp Biol Med 170, 389–394 (2021). https://doi.org/10.1007/s10517-021-05073-y

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Key Words

  • chronic abacterial prostatitis
  • prostate stroma
  • smooth muscle cells
  • endothelial cells
  • ultrastructure