Skip to main content
SpringerLink
Log in

Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax)

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of intraperitoneal administration ACTH(4-7)-PGP in doses of 5, 50, 150, and 450 μg/kg to Wistar male rats 12-15 min before modeling restraint stress on the morphofunctional state of the colon. In rats exposed to restraint stress, signs of atrophy and inflammatory reaction in the colon wall, changes in functional activity and number of mast cells, and increased serum level of corticosterone were observed. Administration of the peptide led to a decrease in corticosterone concentration, alleviated stress-induced pathomorphological changes, and promoted adaptation of the intestinal wall to stress. The positive effects of ACTH(4-7)-PGP can be determined by multifunctional nature of the physiological and pharmacological effects of the neuropeptide.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bakhmet AA, Koplik EV. Antistress effect of Semax in the course of recovery of spleen lymphoid structures after the stress in rats with different behavioral activity. Bull. Exp. Biol. Med. 2012;153(5):661-663. doi: https://doi.org/10.1007/s10517-012-1792-7

    Article  CAS  PubMed  Google Scholar 

  2. Gavrilova SA, Markov MA, Berdalin AB, Kurenkova AD, Koshelev VB. Changes in Sympathetic Innervation of the Heart in Rats with Experimental Myocardial Infarction. Effect of Semax. Bull. Exp. Biol. Med. 2017;163(5):617-619. doi: https://doi.org/10.1007/s10517-017-3862-3

    Article  CAS  PubMed  Google Scholar 

  3. Levitskaya NG, Glazova NYu, Sebentsova EA, Manchenko DM, Vilenskii DA, Andreeva LA, Kamenskii AA, Myasoedov NF. Evaluation of the spectrum of physiological activity of ACTH4-10 analog of heptapeptide Semax. Neirokhimiya. 2008;25(1):111-118. Russian.

    CAS  Google Scholar 

  4. Manchenko DM, Glazova NYu, Levitskaya NG, Andreeva LA, Kamensky AA, Myasoedov NF. Nootropic and analgesic effects of Semax following different routes of administration. Ross. Fiziol. Zh. 2010;96(10):1014-1023. Russian.

    CAS  Google Scholar 

  5. Romanova GA, Silachev DN, Shakova FM, Kvashennikova YN, Viktorov IV, Shram SI, Myasoedov NF. Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex. Bull. Exp. Biol. Med. 2006;142(6):663-666. doi: https://doi.org/10.1007/s10517-006-0445-0

    Article  CAS  PubMed  Google Scholar 

  6. Samotrueva MA, Yasenyavskaya AL, Murtalieva VK, Bashkina OA, Myasoedov NF, Andreeva LA, Karaulov AV. Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress. Bull. Exp. Biol. Med. 2019;166(6):754-758. doi: https://doi.org/10.1007/s10517-019-04434-y

    Article  CAS  PubMed  Google Scholar 

  7. Fadyukova OE, Tyurina AY, Lugovtsov AE, Priezzhev AV, Koshelev VB, Andreeva LA, Myasoedov NF. Semax increases erythrocyte deformability in the shearing blood stream in intact rats and rats with cerebral ischemia. Dokl. Biol. Sci. 2011;439(1):208-211. Russian.

    Article  CAS  Google Scholar 

  8. Choi DC, Nguyen MM, Tamashiro KL, Ma LY, Sakai RR, Herman JP. Chronic social stress in the visible burrow system modulates stress-related gene expression in the bed nucleus of the stria terminalis. Physiol. Behav. 2006;89(3):301-310.

    Article  CAS  Google Scholar 

  9. Hernandez ME, Martinez-Mota L, Salinas C, Marquez-Velasco R, Hernandez-Chan NG, Morales-Montor J, Pérez-Tapia M, Streber ML, Granados-Camacho I, Becerril E, Javier BH, Pavón L. Chronic stress induces structural alterations in splenic lymphoid tissue that are associated with changes in corticosterone levels in Wistar-Kyoto rats. Biomed. Res. Int. 2013;2013:868742. doi: https://doi.org/10.1155/2013/868742

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Khandve B, Gujar V, Bokariya P, Tarnekar A, Shende M. Deranged spermatogenesis of adult Swiss Albino mice as effect of immobilization stress — histological study. Iosr. J. Pharm. 2013;3(2):7-10.

    Google Scholar 

  11. Kim MH, Leem YH. Chronic exercise improves repeated restraint stress-induced anxiety and depression through 5HT1A receptor and cAMP signaling in hippocampus. J. Exerc. Nutrition Biochem. 2014;18(1):97-104.

    Article  Google Scholar 

  12. Popolo A, Autore G, Pinto A, Marzocco S. Oxidative stress in patients with cardiovascular disease and chronic renal failure. Free Radic. Res. 2013;47(5):346-356.

    Article  CAS  Google Scholar 

  13. Troudi A, Bouaziz H, Soudani N, Ben Amara I, Boudawara T, Touzani H, Lyoussi B, Zeghal N. Neurotoxicity and oxidative stress induced by gibberellic acid in rats during late pregnancy and early postnatal periods: Biochemical and histological changes. Exp. Toxicol. Pathol. 2020;64(6):583-590.

    Article  Google Scholar 

  14. Ulrich-Lai YM, Figueiredo HF, Ostrander MM, Choi DC, Engeland WC, Herman JP. Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion-specific manner. Am. J. Physiol. Endocrinol. Metab. 2006;291(5):E965-E973.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia

    M. V. Svishcheva, Ye. S. Mishina, O. A. Medvedeva, I. I. Bobyntsev, A. Y. Mukhina & P. V. Kalutskii

  2. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

    L. A. Andreeva & N. F. Myasoedov

Authors
  1. M. V. Svishcheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ye. S. Mishina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. A. Medvedeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. I. Bobyntsev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Y. Mukhina
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. V. Kalutskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. L. A. Andreeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. N. F. Myasoedov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. I. Bobyntsev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 9, pp. 383-387, September, 2020

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Svishcheva, M.V., Mishina, Y.S., Medvedeva, O.A. et al. Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax). Bull Exp Biol Med 170, 384–388 (2021). https://doi.org/10.1007/s10517-021-05072-z

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-021-05072-z

Key Words

Search

Navigation