Study of Translocation of Stabilized NO Forms through Rat Skin using Electron Paramagnetic Resonance Method

We studied the effect of dinitrosyl-iron complexes with N-acetyl-L-cysteine as a thiol-containing ligand (DNIC-Acc) after transdermal administration to rats. Electron paramagnetic resonance spectroscopy with a lipophilic NO spin trap (a complex of iron and diethyldithiocarbamate ions) showed that DNIC-Acc administration significantly increased the total level of NO in the lung and liver tissues of the animal, which was accompanied by a slight decrease in the mean BP (<10%).

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Correspondence to A. A. Timoshin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 9, pp. 290-295, September, 2020

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Timoshin, A.A., Shumaev, K.B., Lakomkin, V.L. et al. Study of Translocation of Stabilized NO Forms through Rat Skin using Electron Paramagnetic Resonance Method. Bull Exp Biol Med 170, 303–307 (2021). https://doi.org/10.1007/s10517-021-05056-z

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Key Words

  • N-acetyl-L-cysteine
  • dinitrosyl-iron complexes
  • nitric oxide
  • spin trap
  • electron paramagnetic resonance