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Ultrastructural Changes in Hepatocellular Carcinoma-29 Cells after Treatment with Lithium Carbonate

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of lithium carbonate on hepatocellular carcinoma-29 cells in CBA male mice after injection in a dose of 20 mM along the tumor periphery. Transmission electron microscopy revealed a decrease in the volume density of the granular endoplasmic reticulum in the cell cytoplasm and an increase in the total numerical and volume density of autophagosomes and autolysosomes and zones of destruction of intracellular organelles. The ability of lithium carbonate to activate intracellular degradation processes in tumor cells and to stimulate cell death can be used to develop new combined strategies in the chemotherapy for hepatocellular carcinoma.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Siberia, Russia

    Yu. S. Taskaeva & N. P. Bgatova

  2. Novosibirsk National Research State University, Novosibirsk, Russia

    Yu. S. Taskaeva

Authors
  1. Yu. S. Taskaeva
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  2. N. P. Bgatova
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Correspondence to Yu. S. Taskaeva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 1, pp. 94-98, January, 2019

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Taskaeva, Y.S., Bgatova, N.P. Ultrastructural Changes in Hepatocellular Carcinoma-29 Cells after Treatment with Lithium Carbonate. Bull Exp Biol Med 167, 87–90 (2019). https://doi.org/10.1007/s10517-019-04467-3

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  • DOI: https://doi.org/10.1007/s10517-019-04467-3

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