The benign and malignant neoplasms in parotid gland have similar clinical presentations despite different tumor growth rates. The study compared the clinical and morphological data as well as the results of ELISA for MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 in salivary fluid yielded during primary examination of the patients with pleomorphic adenoma and adenocarcinoma of parotid gland. The examined biomarkers detected in salivary fluid in patients with various cancer types differed significantly (p≤0.05). The correlations between clinical identification of adenoma or adenocarcinoma, on the one hand, and the levels of MMP-8, TIMP-1, and TIMP-2, on the other hand, makes it possible to use the latter as biomarkers for early detection and comprehensive noninvasive differential diagnostics of these neoplasms.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Aliev G, Priyadarshini M, Reddy VP, Grieg NH, Kaminsky Y, Cacabelos R, Ashraf GM, Jabir NR, Kamal MA, Nikolenko VN, Zamyatnin AA Jr, Benberin VV, Bachurin SO. Oxidative stress mediated mitochondrial and vascular lesions as markers in the pathogenesis of alzheimer disease. Curr. Med. Chem. 2014;21(19):2208-2217.
Bradley P. General epidemiology and statistics in a defined UK population. Controversies in the Management of Salivary Gland Disease. McGurk M, Renehan A, eds. Oxford, 2001. P. 3-23.
Bergers G, Javaherian K, Lo KM, Folkman J, Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science. 1999;284:808-812.
Comis R. The ECOG Performance Status s in the public domain therefore available for public use. Eastern Cooperative Oncology Group. 2013. URL: http://ecog-acrin.org/resources/ecog-performance-status.
Couch Y, Trofimov A, Markova N, Nikolenko V, Steinbusch HW, Chekhonin V, Schroeter C, Lesch KP, Anthony DC, Strekalova T. Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice. J. Neuroinflammation. 2016;13(1):108. doi: https://doi.org/10.1186/s12974-016-0572-0.
Dzhimak SS, Basov AA, Baryshev MG. Content of deuterium in biological fluids and organs: influence of deuterium depleted water on D/H gradient and the process of adaptation. Dokl. Biochem. and Biophys. 2015;465:370-373.
Golovastova MO, Tsoy LV, Bocharnikova AV, Korolev DO, Gancharova OS, Alekseeva EA, Kuznetsova EB, Savvateeva LV, Skorikova EE, Strelnikov VV, Varshavsky VA, Vinarov AZ, Nikolenko VN, Glybochko PV, Zernii EY, Zamyatnin AA Jr, Bazhin AV, Philippov PP. The cancer-retina antigen recoverin as a potential biomarker for renal tumors. Tumor Biol. 2016;37(7):9899-9907.
Kochurova EV, Nikolenko VN. Estimation of expression of oral fluid biomarkers in the diagnosis of pretumor diseases of oral mucosa. Bull. Exp. Biol. Med. 2017;163(1):87-91.
Kochurova EV, Nikolenko VN. Matrixins in the salivary fluid of patients with tumors of the maxillofacial region during orthopedic rehabilitation with different prosthetic structures. Bull. Exp. Biol. Med. 2017;163(5):663-666.
McGurk М. Benign parotid tumours. BMJ. 2004;329:1299-1300.
Nikolenko VN, Kalmin OV. Method and device for the removal of samples of organs and tissues for histological investigation. Neurosci. Behav. Physiol. 1996;26(3):234-236.
Nikolenko VN, Kozlov SV, Kochurova EV. The effect of risk factors for a malignant neoplasm in the maxillofacial region on the expression of matrix metalloproteinases and their tissue inhibitors in elderly and old patients. Adv. Gerontol. 2015;5(1):50-53.
Pitiyage GN, Lim KP, Gemenitzidis E, Teh MT, Waseem A, Prime SS, Tilakaratne WM, Fortune F, Parkinson EK. Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs -1 and -2) in fibroblasts are early indicators of oral sub-mucous fibrosis and ageing. J. Oral Pathol. Med. 2012;41(6):454-462.
Tilakaratne WM, Ekanayaka RP, Warnakulasuriya S. Oral submucous fibrosis: a historical perspective and a review on etiology and pathogenesis. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 2016;122(2):178-191.
TNM Atlas: Illustrated Guide to the TNM Classification of Malignant Tumours. Wittekind Ch, Asamura H, Sobin LH, eds. Blackwell, 2014.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 9, pp. 358-361, September, 2018
Rights and permissions
About this article
Cite this article
Kochurova, E.V. Comparative Role of Matrixins in Diagnostics of Parotid Gland Tumors. Bull Exp Biol Med 166, 383–385 (2019). https://doi.org/10.1007/s10517-019-04355-w
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-019-04355-w