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Functional State of Various Types of Regeneration-Competent Cells in the Nervous Tissue in Ethanol-Induced Neurodegeneration

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

The in vitro and in vivo models of ethanol-induced neurodegeneration were used to evaluate the content and functional activity of various types of regeneration-competent cells in subventricular zone of the cerebral hemispheres in C57Bl/6JY mice. In nervous tissue culture, ethanol (65 mM) produced no effect on formation of neurospheres. When administered per os in a daily dose of 3 g/kg for 8 weeks, ethanol produced no effect on the number of neural CFU in situ. In both cases, ethanol reduced proliferative activity of neural CFU. Long-term administration of ethanol in vivo suppressed differentiation of neural stem cells and decreased the number of committed precursors (neural cluster-forming units) in the subventricular zone of cerebral hemispheres. In vitro application of ethanol stimulated secretion of humoral growth factors by the cluster-forming neural glial cells. In contrast, in vivo administration of ethanol suppressed this secretion.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    G. N. Zyuz’kov, L. A. Miroshnichenko, E. V. Udut, A. V. Chaikovskii, T. Yu. Polyakova, E. V. Simanina, L. A. Stavrova, V. I. Agafonov & V. V. Zhdanov

Authors
  1. G. N. Zyuz’kov
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  2. L. A. Miroshnichenko
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  3. E. V. Udut
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  4. A. V. Chaikovskii
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  5. T. Yu. Polyakova
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  6. E. V. Simanina
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  7. L. A. Stavrova
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  8. V. I. Agafonov
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  9. V. V. Zhdanov
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Corresponding author

Correspondence to G. N. Zyuz’kov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 9, pp. 286-289, September, 2018

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Zyuz’kov, G.N., Miroshnichenko, L.A., Udut, E.V. et al. Functional State of Various Types of Regeneration-Competent Cells in the Nervous Tissue in Ethanol-Induced Neurodegeneration. Bull Exp Biol Med 166, 317–320 (2019). https://doi.org/10.1007/s10517-019-04341-2

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  • DOI: https://doi.org/10.1007/s10517-019-04341-2

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