Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 6, pp 775–779 | Cite as

Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Secrete Sphingosine-1-Phosphate and Revert Endothelial Injury

  • S. Kasuda
  • R. Kudo
  • K. Yuui
  • Y. Sakurai
  • K. Hatake

The possibility of sphingosine-1-phosphate production by induced pluripotent stem cells is examined to assess their potential in treatment of sepsis. The hematopoietic embryoid bodies were derived from the culture of 6-day-old differentiated induced pluripotent stem cells. These embryoid bodies secreted sphingosine-1-phosphate, an important bioactive lipid that regulates integrity of the pulmonary endothelial barrier, prevents elevation of its permeability, and impedes the formation of stress fibers in human endotheliocytes derived from umbilical vein. The data attest to potentiality of induced pluripotent stem cells in treatment of sepsis.

Key Words

endotheliocytes induced pluripotent stem cells sepsis sphingosine-1-phosphate 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • S. Kasuda
    • 1
  • R. Kudo
    • 1
  • K. Yuui
    • 1
  • Y. Sakurai
    • 2
  • K. Hatake
    • 1
  1. 1.Department of Legal MedicineNara Medical UniversityKashiharaJapan
  2. 2.Department of PediatricsMatsubara Tokushukai HospitalMatsubaraJapan

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