Nanocrystalline particles of chitin in the form of hydrosol in a concentration of 0.63 mg/ml have no effect on aggregation of human platelets and clotting time of platelet-poor plasma in coagulation tests. ADP-induced aggregation of human platelets was inhibited by these nanoparticles in concentrations of 0.63 and 1.00 mg/ml in comparison with the control. Intravenous administration of nanoparticles in a dose of 1 mg/kg to guinea pigs produced no anticoagulant effect. The nanocrystalline particles of chitin can be of interest as potential drug delivery systems.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 12, pp. 739-743, December, 2017
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Drozd, N.N., Torlopov, M.A., Udoratina, E.V. et al. Effect of Nanocrystalline Particles of Chitin on Blood Components in Humans and Experimental Animals. Bull Exp Biol Med 164, 766–769 (2018). https://doi.org/10.1007/s10517-018-4076-z
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DOI: https://doi.org/10.1007/s10517-018-4076-z