Effect of Nanocrystalline Particles of Chitin on Blood Components in Humans and Experimental Animals
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Nanocrystalline particles of chitin in the form of hydrosol in a concentration of 0.63 mg/ml have no effect on aggregation of human platelets and clotting time of platelet-poor plasma in coagulation tests. ADP-induced aggregation of human platelets was inhibited by these nanoparticles in concentrations of 0.63 and 1.00 mg/ml in comparison with the control. Intravenous administration of nanoparticles in a dose of 1 mg/kg to guinea pigs produced no anticoagulant effect. The nanocrystalline particles of chitin can be of interest as potential drug delivery systems.
Key Wordschitin nanoparticles plasma/blood clotting
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- 7.Fornaguera C, Solans C. Methods for the in vitro characterization of nanomedicines-biological component interaction. J. Pers Med. 2017;7(1). pii: E2. doi: https://doi.org/10.3390/jpm7010002.