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Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 6, pp 762–765 | Cite as

Antimetastatic Effect of Liposomal Recombinant Lactaptin

  • V. I. Kaledin
  • O. A. Koval
  • E. V. Kuligina
  • E. L. Lushnikova
  • V. P. Nikolin
  • N. A. Popova
  • I. A. Pyshnaya
  • V. A. Richter
ONCOLOGY

Antimetastatic effect of the liposomal form of recombinant lactaptin RL2 (a proteolytic fragment of human breast milk κ-casein; 8.6 kDa) was studied in A/Sn mice after intravenous transplantation of GA-1 tumor with high rate of liver metastases. Tumor growth in the liver was found in all mice. In animals dying early, the tumors were presented by multiple nodes of about the same size; in mice dying later, the tumors in the liver were presented by just few large nodes formed by cells that survived chemotherapy. A single intravenous injection of RL2 lactaptin in liposomes prolonged lifespan of animals with liver metastases of GA-1 tumor by 1.5 times in comparison with that in untreated animals.

Key Words

A/Sn mice GA-1 transplantable tumor metastases lactaptin liposomes 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • V. I. Kaledin
    • 1
  • O. A. Koval
    • 2
    • 3
  • E. V. Kuligina
    • 2
  • E. L. Lushnikova
    • 4
  • V. P. Nikolin
    • 1
  • N. A. Popova
    • 1
    • 3
  • I. A. Pyshnaya
    • 2
  • V. A. Richter
    • 2
  1. 1.Federal Research Center Institute of Cytology and GeneticsSiberian Division of the Russian Academy of SciencesNovosibirskRussia
  2. 2.Institute of Chemical Biology and Fundamental MedicineSiberian Division of the Russian Academy of SciencesNovosibirskRussia
  3. 3.Novosibirsk National Research State UniversityNovosibirskRussia
  4. 4.Institute of Molecular Pathology and PathomorphologyNovosibirskRussia

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