We studied the role of the carrier status for polymorphic loci of genes encoding estrogen receptors (ESR1), endothelial NO synthase (eNOS), and apolipoprotein E (APOE4) and products of their expression nitrogen oxide (NO) and apolipoprotein (ApoE) in the development of arterial hypertension in men. Conventionally healthy volunteers and 149 men with clinical manifestations of stage I-II arterial hypertension were examined. In men with arterial hypertension, the frequency of minor allele A of ESR1 gene was higher (27.5 vs. 9.5% in the reference group; χ2=4.43, p=0.04). The level of NO in the peripheral blood was also higher in the main group (χ2=3.93, p=0.047). The increase in NO concentration did not depend on the presence of polymorphic genotypes (GG and GT) of eNOS gene, but the decrease in ApoE level in blood serum was associated with TC genotype of APOE4 gene (p=0.04). Our results suggest that minor allele A of ESR1 gene is associated with the development of arterial hypertension in men. Reduced content of ApoE in blood serum of men with arterial hypertension was associated with APOE4 gene polymorphism. However, increased level of NO did not depend on polymorphic genotypes GG and GT of eNOS gene. These polymorphisms are of specific interest as additional markers of genetic predisposition to the development of arterial hypertension in middle-age men.
Similar content being viewed by others
References
Linchak RM. Genetic aspects of arterial hypertension. Vestn. Nats. Med.-Khir. Tsentra im. N. I. Pirogova. 2007;2(1):127-132. Russian.
Metelskaya VA, Oganov RG, Evsikov EM, Teplova NV. Serum NO levels, cardiovascular disease, and concomitant internal pathology in patients with primary arterial hypertension. Ros. Kardiol. Zh. 2011;(4):23-31. Russian.
Makarov MA, Oslopov VN, Korotkov DS, Pavlova KV. Role of genes associated with arterial hypertension in development of oncopathology. Prakt. Med. 2015;(3-2):50-52. Russian.
Pakhomia NS, Uryasev OM, Shakhanov AV. Some genes polymorphism role in arterial hypertension realization. Zemskii Vrach. 2014;(3-4):21-24. Russian.
Smirnov AN. Endocrine Regulation. Biochemical and Physiological Aspects. Moscow, 2009. Russian.
Tereshchenko SN, Zateishchikov DA, Zhirov IV, Nosikov VV, Krasilnikova ES, Karamova IM. Polymorphism of ACE, Angiotensin II, NO synthase, Estrogen Receptor Genes and Gender Differences in Their Effects on Development of Cardiovascular Pathology. Kardiologiya. 2009;49(4):58-62. Russian.
Bredt DS. Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Radic. Res. 1999;31(6):577-596.
Eichner JE, Dunn ST, Perveen G, Thompson DM, Stewart KE, Stroehla BC. Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. Am. J. Epidemiol. 2002;155(6):487-495.
Mendelsohn ME, Karas RH. Molecular and cellular basis of cardiovascular gender differences. Science. 2005;308:1583-1587.
Nilsson M, Dahlman I, Jiao H, Gustafsson JA, Arner P, Dahlman-Wright K. Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis — a cohort study. BMC Med. Genet. 2007;8:73.
Raij L. Nitric oxide and cardiovascular and renal effects. Osteoarthritis. Cartilage. 2008;16(Suppl. 2):S21-S26.
Yang L, Zhang H, Jiang YF, Jin QL, Zhang P, Li X, Gao PJ, Niu JQ. Association of estrogen receptor gene polymorphisms and primary biliary cirrhosis in a chinese population: a casecontrol study. Chin. Med. J. (Engl). 2015;128(22):3008-3014.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 12, pp. 723-727, December, 2017
Rights and permissions
About this article
Cite this article
Dolgikh, O.V., Zaitseva, N.V., Nosov, A.E. et al. Analysis of the Role of Carriership of Polymorphic Genotypes of ESR1, eNOS, and APOE4 Genes in the Development of Arterial Hypertension in Men. Bull Exp Biol Med 164, 753–756 (2018). https://doi.org/10.1007/s10517-018-4073-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-018-4073-2