Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 6, pp 726–729 | Cite as

Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy

  • E. V. Udut
  • P. P. Shchetinin
  • T. V. Rudenko
  • F. Lucieer
  • H. Kingma
  • A. P. Shchetinina
  • M. O. Pleshkov
  • V. P. Demkin
  • V. V. Udut
Article

Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.

Key Words

bilateral vestibular hypofunction vestibular tests etiology vertigo endothelial dysfunction 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Babiyak VI, Gofman VR. Phenomena of interaction between the vestibular and visual analyzers. Novosti Otorinolaringol. Logopatol. 2000;24(4):3-11. Russian.Google Scholar
  2. 2.
    Glantz SA. Primer of Biostatistics. Moscow, 1999. Russian.Google Scholar
  3. 3.
    Dizziness: Differential-Diagnostic Approach in the Practice of an Osteopathologist. Clinical Recommendations. St. Petersburg, 2015. Russian.Google Scholar
  4. 4.
    Zamergrad MV, Parfenov VA, Jahno NN, Mel’nikov OA, Morozova SV. The diagnosis of systemic vertigo in out-patient practice Nevrol. Zh. 2014;19(2):23-29. Russian.Google Scholar
  5. 5.
    Komarsteva IA, Orlova EA, Tarasova MV, Solov’eva IV, Komartseva EV, Zaika AV, Popov EN, Savenko DV, Fillipova OI, Brindak DV, Belous YuA, Khodnevich YaV. The level of nitric oxide in tissues, serum, and mononuclear and mesenchymal stem cells. Ukr. Zh. Klin. Lab. Med. 2009;4(4):133-137. Russian.Google Scholar
  6. 6.
    Kulakova NV, Semiglazova TA, Kseneva SI, Tarasova IV, Mareev IV, Borodulina EV, Udut VV. Nonsteroid antiinflammatory drugs in endothelial dysfunction correction in women with arterial hypertension. Sib. Med. Zh. (Tomsk). 2010;25(4-2):37-39. Russian.Google Scholar
  7. 7.
    Trinus KF. Comparative characteristics of diagnostic methods for dizziness. Nevrologiya, Neiropsikhiatriya, Psikhosomatika. 2012;(3):85-91. Russian.Google Scholar
  8. 8.
    International Classification of Headache Disorders, 3rd ed. London, 2013.Google Scholar
  9. 9.
    Lucieer F, Vonk P, Guinand N, Stokroos R, Kingma H, van de Berg R. Bilateral vestibular hypofunction: Insights in etiologies, clinical subtypes, and diagnostics. Front. Neurol. 2016;7:26. doi:  https://doi.org/10.3389/fneur.2016.00026.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Soloviev MA, Kulakova NV, Semiglazova TA, Borodulina EV, Udut VV. Correction of endothelial dysfunction in patients with arterial hypertension. Bull. Exp. Biol. Med. 2011;151(2):183-185.CrossRefPubMedGoogle Scholar
  11. 11.
    Ward BK, Agrawal Y, Hoffman HJ, Carey JP, Della Santina CC. Prevalence and impact of bilateral vestibular hypofunction: Results from the 2008 US national health interview survey. JAMA Otolaryngol. Head Neck Surg. 2013;139(8):803-810.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • E. V. Udut
    • 1
    • 3
  • P. P. Shchetinin
    • 1
  • T. V. Rudenko
    • 1
  • F. Lucieer
    • 2
  • H. Kingma
    • 1
    • 2
  • A. P. Shchetinina
    • 1
  • M. O. Pleshkov
    • 1
  • V. P. Demkin
    • 1
  • V. V. Udut
    • 1
    • 3
  1. 1.National Research Tomsk State UniversityTomskRussia
  2. 2.Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and NeuroscienceMaastrichtthe Netherlands
  3. 3.E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical CenterRussian Academy of SciencesTomskRussia

Personalised recommendations