Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 5, pp 693–700 | Cite as

Endogenous Regulators of the Immune System (sCD100, Malonic Dialdehyde, and Arginase)

  • A. N. Kazimirskii
  • G. V. Poryadin
  • Zh. M. Salmasi
  • L. Yu. Semenova

Tissue damage in various diseases, hypoxic conditions, and some pathologies are associated with production of endogenous factors such as the soluble form of the surface receptor CD100, malonic dialdehyde, and arginase and their release into circulation. These factors modulate functional state of lymphocytes in the immune system: potentiate activation of B lymphocytes, activate synthesis and secretion of IL-25 and IL-17 cytokines, and suppress proliferative activity of T lymphocytes, thus modulating immunological reactivity of the organism. Reactions of innate and adaptive immunity develop against the background of changed immunological reactivity, which should be taken into account in the development of pathogenetically substantiated therapy.

Key Words

inflammation reactivity sCD100 malonic dialdehyde arginase 


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • A. N. Kazimirskii
    • 1
  • G. V. Poryadin
    • 1
  • Zh. M. Salmasi
    • 1
  • L. Yu. Semenova
    • 1
  1. 1.Department of Pathology and Clinical PathologyN. I. Pirogov Russian National Research Medical University of the Ministry of Health of RussiaMoscowRussia

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