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Re-Examination of the Esophageal Squamous Cell Carcinoma Model in Rats Induced by N-Nitrososarcosine Ethyl Ester Precursors

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Bulletin of Experimental Biology and Medicine Aims and scope

Studies of the molecular mechanisms of esophageal cancer development have to be carried out on sufficient amount of tumor material, obtained under conditions of controlled exposure to carcinogenic factors. Esophageal cancer models on laboratory animals serve an indispensable source of this material. One of these models is esophageal cancer induction in rats by N-nitroso compound precursors. Despite adequate reproduction of human esophageal cancer, this model in fact has not been used since the 1990ies. Re-examination of esophageal cancer model, induced by N-nitrososarcosine ethyl ester precursors, is carried out and its efficiency in induction of squamous cell carcinoma is confirmed.

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References

  1. Alexandrov VA, Novikov AI, Zabezhinsky MA, Stolyarov VI, Petrov AS. The stimulating effect of acetic acid, alcohol and thermal burn injury on esophagus and forestomach carcinogenesis induced by N-nitrososarcosine ethyl ester in rats. Cancer Lett. 1989;47(3):179-185.

    Article  CAS  PubMed  Google Scholar 

  2. Balansky RM, Ganchev G, D’Agostini F, De Flora S. Effects of N-acetylcysteine in an esophageal carcinogenesis model in rats treated with diethylnitrosamine and diethyldithiocarbamate. Int. J. Cancer. 2002;98(4):493-497.

    Article  CAS  PubMed  Google Scholar 

  3. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.0. Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. Lyon, 2013.

  4. Morse MA, Kresty LA, Steele VE, Kelloff GJ, Boone CW, Balentine DA, Harbowy ME, Stoner GD. Effects of theaflavins on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis. Nutr. Cancer. 1997;29(1):7-12.

    Article  CAS  PubMed  Google Scholar 

  5. Peiffer DS, Zimmerman NP, Wang LS, Ransom BW, Carmella SG, Kuo CT, Siddiqui J, Chen JH, Oshima K, Huang YW, Hecht SS, Stoner GD. Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid. Cancer Prev. Res. (Phila). 2014;7(6):574-584.

    Article  CAS  Google Scholar 

  6. Ushida J, Sugie S, Kawabata K, Pham QV, Tanaka T, Fujii K, Takeuchi H, Ito Y, Mori H. Chemopreventive effect of curcumin on N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats. Jpn. J. Cancer Res. 2000;91(9):893-898.

    Article  CAS  PubMed  Google Scholar 

  7. Wheeler JB, Reed CE. Epidemiology of esophageal cancer. Surg. Clin. North. Am. 2012;92(5):1077-1087.

    Article  PubMed  Google Scholar 

  8. Xiang YY, Wang DY, Tanaka M, Igarashi H, Kamo T, Shen Q, Sugimura H, Kino I. Efficient and specific induction of esophageal tumors in rats by precursors of N-nitrososarcosine ethyl ester. Pathol. Int. 1995;45(6):415-421.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Molecular Genetics, the Russian Academy of Sciences, Moscow, Russia

    A. V. Shubin & I. V. Demidyuk

  2. N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia, Moscow, Russia

    E. A. Lesovaya, K. I. Kirsanov, E. E. Antoshina, L. S. Trukhanova, T. G. Gorkova, G. A. Belitsky & M. G. Yakubovskaya

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  1. A. V. Shubin
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  2. E. A. Lesovaya
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  3. K. I. Kirsanov
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  4. E. E. Antoshina
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  5. L. S. Trukhanova
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  6. T. G. Gorkova
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  7. G. A. Belitsky
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  8. M. G. Yakubovskaya
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  9. I. V. Demidyuk
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Correspondence to I. V. Demidyuk.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 11, pp. 633-637, November, 2017

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Shubin, A.V., Lesovaya, E.A., Kirsanov, K.I. et al. Re-Examination of the Esophageal Squamous Cell Carcinoma Model in Rats Induced by N-Nitrososarcosine Ethyl Ester Precursors. Bull Exp Biol Med 164, 676–679 (2018). https://doi.org/10.1007/s10517-018-4057-2

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  • DOI: https://doi.org/10.1007/s10517-018-4057-2

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