Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 5, pp 666–672 | Cite as

Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro

  • I. A. Lyakhova
  • I. S. Bryukhovetsky
  • I. V. Kudryavtsev
  • Yu. S. Khotimchenko
  • M. E. Zhidkov
  • A. V. Kantemirov
Article
  • 13 Downloads

Antitumor efficiency of fascaplysin synthetic derivatives (7-phenylfascaplysin, 3-chlorofascaplysin, 3-bromofascaplysin, and 10-bromofascaplysin) was compared out in vitro on C6 glioma cells. The cytotoxic efficiency of all tested compounds was higher than that of unsubstituted fascaplysin; 3-bromofascaplysin and 7-phenylfascaplysin exhibited the best capacity to kill glioma C6 cells. Apoptosis was the main mechanism of glioma cell death. The cytotoxic activity of these compounds increased with prolongation of exposure to the substance and increase of its concentration. Fascaplysin derivatives modified all phases of glioma cell vital cycle. The count of viable tumor cell in G0 phase remained minimum by the end of experiment under the effects of 3-bromofascaplysin and 7-phenylfascaplysin.

Key Words

fascaplysin 3-bromofascaplysin glia tumors apoptosis cell cycle 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • I. A. Lyakhova
    • 1
  • I. S. Bryukhovetsky
    • 1
    • 2
  • I. V. Kudryavtsev
    • 1
  • Yu. S. Khotimchenko
    • 1
    • 2
  • M. E. Zhidkov
    • 1
  • A. V. Kantemirov
    • 1
  1. 1.Biomedicine School, Far-Eastern Federal UniversityVladivostokRussia
  2. 2.A. V. Zhirmunsky Institute of Marine BiologyFar-Eastern Division of the Russian Academy of SciencesVladivostokRussia

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