Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 5, pp 650–654 | Cite as

Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes

  • S. V. Nikulin
  • M. P. Raigorodskaya
  • A. A. Poloznikov
  • G. S. Zakharova
  • U. Schumacher
  • D. Wicklein
  • C. Stürken
  • K. Riecken
  • K. A. Fomicheva
  • B. Ya. Alekseev
  • M. Yu. Shkurnikov
GENETICS
  • 8 Downloads

Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.

Key Words

IGFBP6 epithelial-mesenchymal transition metastases relapse MDA-MB-231 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • S. V. Nikulin
    • 1
    • 2
  • M. P. Raigorodskaya
    • 1
  • A. A. Poloznikov
    • 1
  • G. S. Zakharova
    • 1
  • U. Schumacher
    • 4
  • D. Wicklein
    • 4
  • C. Stürken
    • 4
  • K. Riecken
    • 4
  • K. A. Fomicheva
    • 3
  • B. Ya. Alekseev
    • 3
  • M. Yu. Shkurnikov
    • 3
  1. 1.BioClinicum CenterMoscowRussia
  2. 2.Moscow Institute of Physics and Technology (MIPT)MoscowRussia
  3. 3.P. A. Hertsen Moscow Oncology Research CenterBranch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian FederationMoscowRussia
  4. 4.University Medical Center Hamburg-EppendorfHamburgGermany

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