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GABAergic Mechanism of Anticonvulsive Effect of Chemical Agent RU-1205

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The study examined the effect of 9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo[1,2-α] benzimidazole dihydrochloride (RU-1205) on the latency of seizures provoked by corazol, bicuculline, or picrotoxin. This agent (10 and 20 mg/kg) increased the seizure latency in the experimental models of epileptogenesis. The blockers of GABAA and GABA A -ρ receptors picrotoxin and (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid, respectively, were employed to study the effects of RU-1205 on electrical activity of somatosensory cortical neurons and on formation of pathological rhythms in the rat brain. RU-1205 inhibited the focal background rhythm and eliminated the epileptiform activity, which can be mediated by interaction with GABAA receptors.

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Correspondence to K. Yu. Kalitin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 11, pp. 582-588, November, 2017

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Kalitin, K.Y., Grechko, O.Y., Spasov, A.A. et al. GABAergic Mechanism of Anticonvulsive Effect of Chemical Agent RU-1205. Bull Exp Biol Med 164, 629–635 (2018). https://doi.org/10.1007/s10517-018-4047-4

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  • DOI: https://doi.org/10.1007/s10517-018-4047-4

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