Compounds of IL-6 Receptor Complex during Acute Lung Injury
- 28 Downloads
Soluble receptor of IL-6 (sIL-6R) and antagonist of the receptor complex, soluble glycoprotein 130 (sgp130) mediate opposite effects during inflammation. We measured the levels of these cytokines and their ratio in rat blood on the model of acute lung injury. The injury was modeled by the intratracheal administration of LPS. The levels of sgp130 and sIL-6R increased during the inflammatory process in the injured lungs. The sgp130/sIL-6R ratio increased or decreased depending on the intensity of the inflammatory process. sgp130/sIL-6R ratio might reflect the intensity of inflammation during lung injury.
Key Wordsinflammation soluble receptor of IL-6 sgp130 acute lung injury
Unable to display preview. Download preview PDF.
- 1.Simbirtsev AS. Oytokines in the pathogenesis of infectious and noninfectious human diseases. Med. Akad. Zh. 2013;(3):18-41. Russian.Google Scholar
- 2.Gonzales JN, Lucas R, Verin AD. The acute respiratory distress syndrome: mechanisms and perspective therapeutic approaches. Austin J. Vasc. Med. 2015;2(1):pii: 1009.Google Scholar