Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 5, pp 609–611 | Cite as

Compounds of IL-6 Receptor Complex during Acute Lung Injury

  • D. A. Chepurnova
  • E. V. Samoilova
  • A. A. Anisimov
  • A. D. Verin
  • A. A. Korotaeva
Article
  • 13 Downloads

Soluble receptor of IL-6 (sIL-6R) and antagonist of the receptor complex, soluble glycoprotein 130 (sgp130) mediate opposite effects during inflammation. We measured the levels of these cytokines and their ratio in rat blood on the model of acute lung injury. The injury was modeled by the intratracheal administration of LPS. The levels of sgp130 and sIL-6R increased during the inflammatory process in the injured lungs. The sgp130/sIL-6R ratio increased or decreased depending on the intensity of the inflammatory process. sgp130/sIL-6R ratio might reflect the intensity of inflammation during lung injury.

Key Words

inflammation soluble receptor of IL-6 sgp130 acute lung injury 

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • D. A. Chepurnova
    • 1
  • E. V. Samoilova
    • 1
  • A. A. Anisimov
    • 1
  • A. D. Verin
    • 2
  • A. A. Korotaeva
    • 1
  1. 1.National Medical Research Center of СardiologyMinistry of Healthcare of the Russian FederationMoscowRussia
  2. 2.Augusta UniversityAugustaUSA

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