Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 5, pp 591–595 | Cite as

Assessment of Cardiac Vegetative Control during Acute Graduated Exogenous Normobaric Hypoxia in Rats

  • V. N. Kotel’nikov
  • I. O. Osipov
  • Yu. V. Zayats
  • B. I. Gel’tser

The effects of exogenous normobaric hypoxic hypoxia on vegetative control of the heart and BP were examined in Wistar rats. The reference ranges of variation pulsometry parameters were determined in rats with normoxemia for 3 physiological variants of autonomic homeostasis: eutony, sympathicotony, and vagotony. Most rats (80%) demonstrated autonomic eutony. The study showed that saturation of arterial blood with oxygen is the most adequate assessment of severity of acute exogenous normobaric hypoxic hypoxia progressing within a closed hypoxic chamber, which standardizes this method and minimizes inaccuracies resulting from individual sensitivity to hypoxic stress. The changes in functional activity of systems that control the heart rhythm closely correlated with the drop in arterial blood oxygenation. While a small arterial hypoxemia activated the ergotropic elements of autonomic nervous system central subdivision accompanied by elevation of systolic BP, the moderate hypoxemia augmented the cholinergic influences and moderated the adrenergic ones under maintaining mobilization of the central autonomic nervous system-control loop and normotension. Severe hypoxemia was manifested by augmented influences from autonomic nervous system central subdivisions on the heart rate, disadaptation of the control systems, and systolic-diastolic arterial hypotension.

Key Words

normobaric hypoxia cardiac autonomic control blood pressure 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • V. N. Kotel’nikov
    • 1
    • 2
  • I. O. Osipov
    • 2
  • Yu. V. Zayats
    • 3
  • B. I. Gel’tser
    • 3
  1. 1.Far-Eastern Division of State Scientific Research Testing Institute of Military MedicineMinistry of Defense of the Russian FederationVladivostokRussia
  2. 2.Pacific State Medical University, Ministry of Health of the Russian FederationVladivostokRussia
  3. 3.Far-Eastern Federal University, Ministry of Education and Science of the Russian FederationVladivostokRussia

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