Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 4, pp 493–496 | Cite as

Changes in Canonical β-Catenin/Wnt Signaling Activation in the Adrenal Cortex of Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Prenatal and Postnatal Ontogeny

  • D. A. Tsomartova
  • N. V. Yaglova
  • V. V. Yaglov

Prenatal and postnatal exposure to low doses of the endocrine disruptor dichlorodiphenyltrichloroethane (DDT) leads to delayed activation of the canonical β-catenin/Wnt signaling in zona glomerulosa and zona reticularis of the adrenal cortex in rats, which changed the rate of their postnatal development. Suppression of the Wnt pathway in zona fasciculata promotes its regeneration after DDT-induced blood circulation disorders and cell death.

Key Words

β-catenin Wnt signaling adrenal endocrine disruptors DDT 


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  1. 1.
    Yaglova NV, Yaglov VV. Mechanisms of Disruptive Action of Dichlorodiphenyltrichloroethane (DDT) on the Function of Thyroid Follicular Epitheliocytes. Bull. Exp. Biol. Med. 2015;160(2):231-233.CrossRefPubMedGoogle Scholar
  2. 2.
    Bergman A. Health condition of the Baltic grey seal (Halichoerus grypus) during two decades. Gynaecological health improvement but increased prevalence of colonic ulcers. APMIS. 1999;107(3):270-282.CrossRefPubMedGoogle Scholar
  3. 3.
    Berthon A, Martinez A, Bertherat J, Val P. Wnt/β-catenin signalling in adrenal physiology and tumour development. Mol. Cell. Endocrinol. 2012;351(1):87-95.CrossRefPubMedGoogle Scholar
  4. 4.
    Brembeck FH, Rosário M, Birchmeier W. Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr. Opin. Genet. Dev. 2006;16(1):51-59.CrossRefPubMedGoogle Scholar
  5. 5.
    Drelon C, Berthon A, Mathieu M, Martinez A, Val P. Adrenal cortex tissue homeostasis and zonation: a WNT perspective. Mol. Cell. Endocrinol. 2015;408:156-164.CrossRefPubMedGoogle Scholar
  6. 6.
    Endocrine disruptors and children health. Possible developmental early effects of endocrine disruptors on children health. WHO, 2012.Google Scholar
  7. 7.
    Kim W, Kim M, Jho EH. Wnt/b-catenin signalling: from plasma membrane to nucleus. Biochem. J. 2013;450(1):9-21.CrossRefPubMedGoogle Scholar
  8. 8.
    Lindhe O, Skogseid B, Brandt I. Cytochrome P450-catalyzed binding of 3-Methylsulfonyl-DDE and o,p-DDD in human adrenal zona fasciculata/reticularis. J. Clin. Endocrinol. Metab. 2002;87(3):1319-1326.PubMedGoogle Scholar
  9. 9.
    Pignatelli D, Xiao F, Gouveia AM, Ferreira JG, Vinson GP. Adrenarche in the rat. J. Endocrinol. 2006;191(1):301-308.CrossRefPubMedGoogle Scholar
  10. 10.
    Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr, Lee DH, Shioda T, Soto AM, vom Saal FS, Welshons WV, Zoeller RT, Myers JP. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr. Rev. 2012;33(3):378-455.Google Scholar
  11. 11.
    Walczak EM, Kuick R, Finco I, Bohin N, Hrycaj SM, Wellik DM, Hammer GD. Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms. Mol. Endocrinol. 2014;28(9):1471-1486.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • D. A. Tsomartova
    • 1
  • N. V. Yaglova
    • 1
  • V. V. Yaglov
    • 1
  1. 1.Research Institute of Human MorphologyMoscowRussia

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