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Bulletin of Experimental Biology and Medicine

, Volume 164, Issue 4, pp 493–496 | Cite as

Changes in Canonical β-Catenin/Wnt Signaling Activation in the Adrenal Cortex of Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Prenatal and Postnatal Ontogeny

  • D. A. Tsomartova
  • N. V. Yaglova
  • V. V. Yaglov
Article
  • 23 Downloads

Prenatal and postnatal exposure to low doses of the endocrine disruptor dichlorodiphenyltrichloroethane (DDT) leads to delayed activation of the canonical β-catenin/Wnt signaling in zona glomerulosa and zona reticularis of the adrenal cortex in rats, which changed the rate of their postnatal development. Suppression of the Wnt pathway in zona fasciculata promotes its regeneration after DDT-induced blood circulation disorders and cell death.

Key Words

β-catenin Wnt signaling adrenal endocrine disruptors DDT 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • D. A. Tsomartova
    • 1
  • N. V. Yaglova
    • 1
  • V. V. Yaglov
    • 1
  1. 1.Research Institute of Human MorphologyMoscowRussia

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